Bmps as mediators of roof plate repulsion of commissural neurons

Adela Augsburger, Anita Schuchardt, Sally Hoskins, Jane Dodd, Samantha Butler

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

During spinal cord development, commissural (C) neurons, located near the dorsal midline, send axons ventrally and across the floor plate (FP). The trajectory of these axons toward the FP is guided in part by netrins. The mechanisms that guide the early phase of C axon extension, however, have not been resolved. We show that the roof plate (RP) expresses a diffusible activity that repels C axons and orients their growth within the dorsal spinal cord. Bone morphogenetic proteins (BMPs) appear to act as RP-derived chemorepellents that guide the early trajectory of the axons of C neurons in the developing spinal cord: BMP7 mimics the RP repellent activity for C axons in vitro, can act directly to collapse C growth cones, and appears to serve an essential function in RP repulsion of C axons.

Original languageEnglish (US)
Pages (from-to)127-141
Number of pages15
JournalNeuron
Volume24
Issue number1
DOIs
StatePublished - Jan 1 1999

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Axons
Neurons
Spinal Cord
Growth Cones
Bone Morphogenetic Proteins
Growth

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Bmps as mediators of roof plate repulsion of commissural neurons. / Augsburger, Adela; Schuchardt, Anita; Hoskins, Sally; Dodd, Jane; Butler, Samantha.

In: Neuron, Vol. 24, No. 1, 01.01.1999, p. 127-141.

Research output: Contribution to journalArticle

Augsburger, A, Schuchardt, A, Hoskins, S, Dodd, J & Butler, S 1999, 'Bmps as mediators of roof plate repulsion of commissural neurons', Neuron, vol. 24, no. 1, pp. 127-141. https://doi.org/10.1016/S0896-6273(00)80827-2
Augsburger, Adela ; Schuchardt, Anita ; Hoskins, Sally ; Dodd, Jane ; Butler, Samantha. / Bmps as mediators of roof plate repulsion of commissural neurons. In: Neuron. 1999 ; Vol. 24, No. 1. pp. 127-141.
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