BMI and diabetes risk in Singaporean Chinese

Andrew O. Odegaard; Woon Puay Koh; Gabrielle Vazquez; Kazuko Arakawa; Hin Peng Lee; Mimi C. Yu; Mark A. Pereira

doi:10.2337/dc08-1674

BMI and diabetes risk in Singaporean Chinese

Andrew O. Odegaard, Woon Puay Koh, Gabrielle Vazquez, Kazuko Arakawa, Hin Peng Lee, Mimi C. Yu, Mark A. Pereira

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE - Increased BMI is a robust risk factor for type 2 diabetes. Paradoxically, South Asians have relatively low BMIs despite their high prevalence of type 2 diabetes. We examined the association between BMI and incident type 2 diabetes because detailed prospective cohort data on this topic in Asians are scarce. RESEARCH DESIGN AND METHODS - This study was a prospective analysis of 37,091 men and women aged 45-74 years in the Singapore Chinese Health Study, using Cox regression analysis. RESULTS - Risk of incident type 2 diabetes significantly increased beginning with BMIs 18.5-23.0 kg/m² (relative risk 2.47 [95% CI 1.75-3.48]) and continued in a monotonic fashion across the spectrum of BMI. Results were stronger for younger than for older adults. CONCLUSIONS - BMIs considered lean and normal in Singaporean Chinese are strongly associated with increased risk of incident type 2 diabetes. This association weakened with advanced age but remained significant.

Original language	English (US)
Pages (from-to)	1104-1106
Number of pages	3
Journal	Diabetes care
Volume	32
Issue number	6
DOIs	https://doi.org/10.2337/dc08-1674
State	Published - Jun 2009

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title = "BMI and diabetes risk in Singaporean Chinese",

abstract = "OBJECTIVE - Increased BMI is a robust risk factor for type 2 diabetes. Paradoxically, South Asians have relatively low BMIs despite their high prevalence of type 2 diabetes. We examined the association between BMI and incident type 2 diabetes because detailed prospective cohort data on this topic in Asians are scarce. RESEARCH DESIGN AND METHODS - This study was a prospective analysis of 37,091 men and women aged 45-74 years in the Singapore Chinese Health Study, using Cox regression analysis. RESULTS - Risk of incident type 2 diabetes significantly increased beginning with BMIs 18.5-23.0 kg/m2 (relative risk 2.47 [95% CI 1.75-3.48]) and continued in a monotonic fashion across the spectrum of BMI. Results were stronger for younger than for older adults. CONCLUSIONS - BMIs considered lean and normal in Singaporean Chinese are strongly associated with increased risk of incident type 2 diabetes. This association weakened with advanced age but remained significant.",

author = "Odegaard, {Andrew O.} and Koh, {Woon Puay} and Gabrielle Vazquez and Kazuko Arakawa and Lee, {Hin Peng} and Yu, {Mimi C.} and Pereira, {Mark A.}",

year = "2009",

month = jun,

doi = "10.2337/dc08-1674",

language = "English (US)",

volume = "32",

pages = "1104--1106",

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publisher = "American Diabetes Association Inc.",

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TY - JOUR

T1 - BMI and diabetes risk in Singaporean Chinese

AU - Odegaard, Andrew O.

AU - Koh, Woon Puay

AU - Vazquez, Gabrielle

AU - Arakawa, Kazuko

AU - Lee, Hin Peng

AU - Yu, Mimi C.

AU - Pereira, Mark A.

PY - 2009/6

Y1 - 2009/6

N2 - OBJECTIVE - Increased BMI is a robust risk factor for type 2 diabetes. Paradoxically, South Asians have relatively low BMIs despite their high prevalence of type 2 diabetes. We examined the association between BMI and incident type 2 diabetes because detailed prospective cohort data on this topic in Asians are scarce. RESEARCH DESIGN AND METHODS - This study was a prospective analysis of 37,091 men and women aged 45-74 years in the Singapore Chinese Health Study, using Cox regression analysis. RESULTS - Risk of incident type 2 diabetes significantly increased beginning with BMIs 18.5-23.0 kg/m2 (relative risk 2.47 [95% CI 1.75-3.48]) and continued in a monotonic fashion across the spectrum of BMI. Results were stronger for younger than for older adults. CONCLUSIONS - BMIs considered lean and normal in Singaporean Chinese are strongly associated with increased risk of incident type 2 diabetes. This association weakened with advanced age but remained significant.

AB - OBJECTIVE - Increased BMI is a robust risk factor for type 2 diabetes. Paradoxically, South Asians have relatively low BMIs despite their high prevalence of type 2 diabetes. We examined the association between BMI and incident type 2 diabetes because detailed prospective cohort data on this topic in Asians are scarce. RESEARCH DESIGN AND METHODS - This study was a prospective analysis of 37,091 men and women aged 45-74 years in the Singapore Chinese Health Study, using Cox regression analysis. RESULTS - Risk of incident type 2 diabetes significantly increased beginning with BMIs 18.5-23.0 kg/m2 (relative risk 2.47 [95% CI 1.75-3.48]) and continued in a monotonic fashion across the spectrum of BMI. Results were stronger for younger than for older adults. CONCLUSIONS - BMIs considered lean and normal in Singaporean Chinese are strongly associated with increased risk of incident type 2 diabetes. This association weakened with advanced age but remained significant.

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JO - Diabetes care

JF - Diabetes care

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ER -

BMI and diabetes risk in Singaporean Chinese

Abstract

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