Blueberry muffin rash, hyperbilirubinemia, and hypoglycemia: A case of hemolytic disease of the fetus and newborn due to anti-Kpa

J. E. Brumbaugh, S. Morgan, J. C. Beck, N. Zantek, S. Kearney, C. M. Bendel, K. D. Roberts

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Hemolytic disease of the fetus and newborn occurs when maternal IgG antibodies cross the placenta and cause hemolysis of fetal red blood cells. Kp a is a low frequency red blood cell antigen that has rarely been implicated in hemolytic disease of the fetus and newborn. The few reported cases attributed to anti-Kp a have typically had minimal clinical consequences. We report a critically ill neonate who presented with purpura, respiratory failure, severe liver dysfunction, hyperbilirubinemia, hypoglycemia and anemia. This case report broadens the spectrum of neonatal disease associated with anti-Kp a, addresses the evaluation of hemolysis with liver failure in a neonate, and emphasizes the importance of screening for antibodies to low frequency red blood cell antigens in suspected hemolytic disease of the fetus and newborn.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalJournal of Perinatology
Volume31
Issue number5
DOIs
StatePublished - May 2011

Bibliographical note

Funding Information:
Drs Beck, Bendel, Brumbaugh, Kearney, Morgan and Roberts declare no conflict of interests. Dr Zantek’s work has been funded in part by a research grant from Verax Biomedical, Inc., and she has received royalties from MedImmune.

Keywords

  • Kell
  • Kp
  • blueberry muffin rash
  • extramedullary hematopoiesis
  • hemolytic disease of the fetus and newborn
  • hyperbilirubinemia

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