While patient engagement has been named as the blockbuster drug of the century, our understanding of how to effectively engage and empower consumers, for positive outcomes, is nascent and an emerging science. The effectiveness component will be especially crucial aswe consider new technologies to enable health information access, action, and exchange and patient-generated health data. Three million nurses, touching 18 million patients annually, are in a unique position to share resources with patients and begin the transition to patient access to health records online. The more nurses, themselves, are engaged in their own care throughHIT, the more likely it is that they can involve patients in understanding and accessing HIT. Bedside nurses, educators, administrators, and researchers can all join in the movement to increase the use of HIT. As a profession, nurses are a powerful voice, and we have the ability to transform healthcare by actively engaging ourselves and the patients we serve.