Blood pressure and white matter integrity in geriatric depression

Matthew J. Hoptman; Faith M. Gunning-Dixon; Christopher F. Murphy; Babak A. Ardekani; Jan Hrabe; Kelvin O. Lim; Glenda R. Etwaroo; Dora Kanellopoulos; George S. Alexopoulos

doi:10.1016/j.jad.2008.07.024

Blood pressure and white matter integrity in geriatric depression

Matthew J. Hoptman
, Faith M. Gunning-Dixon
, Christopher F. Murphy
, Babak A. Ardekani
, Jan Hrabe
, Kelvin O. Lim
, Glenda R. Etwaroo
, Dora Kanellopoulos
, George S. Alexopoulos

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background: Cerebrovascular disease may increase vulnerability to geriatric depression, a syndrome often accompanied by frontal-subcortical lesions. High blood pressure is a risk factor for cerebrovascular disease and white matter changes. This study examined whether and in which brain regions blood pressure is associated with compromised white matter integrity in elderly depressed patients. Methods: We studied the association between blood pressure and white matter integrity assessed by diffusion tensor imaging (fractional anisotropy, FA) in 41 older patients with major depression. Correlations between FA and blood pressure, after controlling for age, were examined with a voxelwise analysis. Results: Significant associations between FA and blood pressure were detected throughout the anterior cingulate and in multiple frontostriatal and frontotemporal regions. Limitations: This study did not employ a healthy control group. Moreover, the relatively small sample size precluded a comparison of patients with and without hypertension. Conclusions: Compromised frontal-striatal white matter integrity may be the anatomical background through which blood pressure confers vulnerability to depression.

Original language	English (US)
Pages (from-to)	171-176
Number of pages	6
Journal	Journal of Affective Disorders
Volume	115
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jad.2008.07.024
State	Published - May 2009

Bibliographical note

Funding Information:
This work was supported by NIMH Grants RO1 MH65653 (GSA), K23 MH067702 (CFM), P30 MH68638 (GSA), and K23 MH074818 (FMG-D) and by the Sanchez Foundation. The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.

Funding Information:
Dr. Alexopoulos has received research grants by Forest Pharmaceuticals, Inc. and Cephalon and participated in scientific advisory board meetings of Forest Pharmaceuticals, Novartis, and Sanofi-Aventis. He has given lectures supported by Forest, Cephalon, Bristol Meyers Squibb, Janssen, Pfizer, Glaxo, and Lilly and has received support by Comprehensive Neuroscience, Inc. for the development of treatment guidelines in late-life psychiatric disorders. All other authors declare that they have no conflicts of interest.

Funding Information:
This work was supported by NIMH Grants RO1 MH65653 (GSA), K23 MH067702 (CFM), P30 MH068638 (GSA), and K23 MH074818 (FMG-D) and by the TRU and Sanchez Foundations. We thank Laurie Nash, MA, Margaret E. Bloomer, BS, Susan N. Boyer, MA, and Jessica Shields, BA, for their assistance in patient recruitment and study coordination, and Raj Sangoi, RT(R)MR for his work as chief MR technologist.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cardiovascular risk
Diffusion tensor imaging
Geriatric depression

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10.1016/j.jad.2008.07.024

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@article{1f4ca4f1f42b46b9961ca036c7563da7,

title = "Blood pressure and white matter integrity in geriatric depression",

abstract = "Background: Cerebrovascular disease may increase vulnerability to geriatric depression, a syndrome often accompanied by frontal-subcortical lesions. High blood pressure is a risk factor for cerebrovascular disease and white matter changes. This study examined whether and in which brain regions blood pressure is associated with compromised white matter integrity in elderly depressed patients. Methods: We studied the association between blood pressure and white matter integrity assessed by diffusion tensor imaging (fractional anisotropy, FA) in 41 older patients with major depression. Correlations between FA and blood pressure, after controlling for age, were examined with a voxelwise analysis. Results: Significant associations between FA and blood pressure were detected throughout the anterior cingulate and in multiple frontostriatal and frontotemporal regions. Limitations: This study did not employ a healthy control group. Moreover, the relatively small sample size precluded a comparison of patients with and without hypertension. Conclusions: Compromised frontal-striatal white matter integrity may be the anatomical background through which blood pressure confers vulnerability to depression.",

keywords = "Cardiovascular risk, Diffusion tensor imaging, Geriatric depression",

author = "Hoptman, \{Matthew J.\} and Gunning-Dixon, \{Faith M.\} and Murphy, \{Christopher F.\} and Ardekani, \{Babak A.\} and Jan Hrabe and Lim, \{Kelvin O.\} and Etwaroo, \{Glenda R.\} and Dora Kanellopoulos and Alexopoulos, \{George S.\}",

note = "Funding Information: This work was supported by NIMH Grants RO1 MH65653 (GSA), K23 MH067702 (CFM), P30 MH68638 (GSA), and K23 MH074818 (FMG-D) and by the Sanchez Foundation. The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Funding Information: Dr. Alexopoulos has received research grants by Forest Pharmaceuticals, Inc. and Cephalon and participated in scientific advisory board meetings of Forest Pharmaceuticals, Novartis, and Sanofi-Aventis. He has given lectures supported by Forest, Cephalon, Bristol Meyers Squibb, Janssen, Pfizer, Glaxo, and Lilly and has received support by Comprehensive Neuroscience, Inc. for the development of treatment guidelines in late-life psychiatric disorders. All other authors declare that they have no conflicts of interest. Funding Information: This work was supported by NIMH Grants RO1 MH65653 (GSA), K23 MH067702 (CFM), P30 MH068638 (GSA), and K23 MH074818 (FMG-D) and by the TRU and Sanchez Foundations. We thank Laurie Nash, MA, Margaret E. Bloomer, BS, Susan N. Boyer, MA, and Jessica Shields, BA, for their assistance in patient recruitment and study coordination, and Raj Sangoi, RT(R)MR for his work as chief MR technologist.",

year = "2009",

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doi = "10.1016/j.jad.2008.07.024",

language = "English (US)",

volume = "115",

pages = "171--176",

journal = "Journal of Affective Disorders",

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TY - JOUR

T1 - Blood pressure and white matter integrity in geriatric depression

AU - Hoptman, Matthew J.

AU - Gunning-Dixon, Faith M.

AU - Murphy, Christopher F.

AU - Ardekani, Babak A.

AU - Hrabe, Jan

AU - Lim, Kelvin O.

AU - Etwaroo, Glenda R.

AU - Kanellopoulos, Dora

AU - Alexopoulos, George S.

N1 - Funding Information: This work was supported by NIMH Grants RO1 MH65653 (GSA), K23 MH067702 (CFM), P30 MH68638 (GSA), and K23 MH074818 (FMG-D) and by the Sanchez Foundation. The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Funding Information: Dr. Alexopoulos has received research grants by Forest Pharmaceuticals, Inc. and Cephalon and participated in scientific advisory board meetings of Forest Pharmaceuticals, Novartis, and Sanofi-Aventis. He has given lectures supported by Forest, Cephalon, Bristol Meyers Squibb, Janssen, Pfizer, Glaxo, and Lilly and has received support by Comprehensive Neuroscience, Inc. for the development of treatment guidelines in late-life psychiatric disorders. All other authors declare that they have no conflicts of interest. Funding Information: This work was supported by NIMH Grants RO1 MH65653 (GSA), K23 MH067702 (CFM), P30 MH068638 (GSA), and K23 MH074818 (FMG-D) and by the TRU and Sanchez Foundations. We thank Laurie Nash, MA, Margaret E. Bloomer, BS, Susan N. Boyer, MA, and Jessica Shields, BA, for their assistance in patient recruitment and study coordination, and Raj Sangoi, RT(R)MR for his work as chief MR technologist.

PY - 2009/5

Y1 - 2009/5

N2 - Background: Cerebrovascular disease may increase vulnerability to geriatric depression, a syndrome often accompanied by frontal-subcortical lesions. High blood pressure is a risk factor for cerebrovascular disease and white matter changes. This study examined whether and in which brain regions blood pressure is associated with compromised white matter integrity in elderly depressed patients. Methods: We studied the association between blood pressure and white matter integrity assessed by diffusion tensor imaging (fractional anisotropy, FA) in 41 older patients with major depression. Correlations between FA and blood pressure, after controlling for age, were examined with a voxelwise analysis. Results: Significant associations between FA and blood pressure were detected throughout the anterior cingulate and in multiple frontostriatal and frontotemporal regions. Limitations: This study did not employ a healthy control group. Moreover, the relatively small sample size precluded a comparison of patients with and without hypertension. Conclusions: Compromised frontal-striatal white matter integrity may be the anatomical background through which blood pressure confers vulnerability to depression.

AB - Background: Cerebrovascular disease may increase vulnerability to geriatric depression, a syndrome often accompanied by frontal-subcortical lesions. High blood pressure is a risk factor for cerebrovascular disease and white matter changes. This study examined whether and in which brain regions blood pressure is associated with compromised white matter integrity in elderly depressed patients. Methods: We studied the association between blood pressure and white matter integrity assessed by diffusion tensor imaging (fractional anisotropy, FA) in 41 older patients with major depression. Correlations between FA and blood pressure, after controlling for age, were examined with a voxelwise analysis. Results: Significant associations between FA and blood pressure were detected throughout the anterior cingulate and in multiple frontostriatal and frontotemporal regions. Limitations: This study did not employ a healthy control group. Moreover, the relatively small sample size precluded a comparison of patients with and without hypertension. Conclusions: Compromised frontal-striatal white matter integrity may be the anatomical background through which blood pressure confers vulnerability to depression.

KW - Cardiovascular risk

KW - Diffusion tensor imaging

KW - Geriatric depression

UR - https://www.scopus.com/pages/publications/62649114457

UR - https://www.scopus.com/pages/publications/62649114457#tab=citedBy

U2 - 10.1016/j.jad.2008.07.024

DO - 10.1016/j.jad.2008.07.024

M3 - Article

C2 - 18805589

AN - SCOPUS:62649114457

SN - 0165-0327

VL - 115

SP - 171

EP - 176

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

IS - 1-2

ER -

Blood pressure and white matter integrity in geriatric depression

Abstract

Bibliographical note

UN SDGs

Keywords

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