Blood pressure and cardiac performance

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The factors which control the performance of the left ventricle include the determinants of myocardial function (preload, afterload, contractility and heart rate) and peripheral vascular function (capacitance and impedance). Arterial pressure represents an interaction of myocardial and vascular factors. When left ventricular function becomes impaired, impedance to left ventricular ejection becomes increasingly important in determining cardiac performance. Increases in impedance may result from the influence on arteries of neural, humoral or structural changes which can occur in response to a fall in cardiac output or an impairment of cardiac reserve. This increased impedance may further reduce cardiac output while myocardial oxygen consumption is increased. Alterations in the peripheral vascular bed therefore probably play an important role in the hemodynamic and metabolic events which usually are attributed to progressive impairment of the heart. Pharmacologie reduction of impedance with vasodilator drugs could become an important adjunct in the management of heart failure of diverse etiologies.

Original languageEnglish (US)
Pages (from-to)351-361
Number of pages11
JournalThe American Journal of Medicine
Volume55
Issue number3
DOIs
StatePublished - Sep 1973
Externally publishedYes

Fingerprint

Electric Impedance
Blood Pressure
Cardiac Output
Vascular Capacitance
Vasodilator Agents
Left Ventricular Function
Oxygen Consumption
Heart Ventricles
Blood Vessels
Arterial Pressure
Heart Failure
Arteries
Heart Rate
Hemodynamics

Cite this

Blood pressure and cardiac performance. / Cohn, Jay N.

In: The American Journal of Medicine, Vol. 55, No. 3, 09.1973, p. 351-361.

Research output: Contribution to journalArticle

@article{0467801cd8a34edfbd2729ba5c1acd3f,
title = "Blood pressure and cardiac performance",
abstract = "The factors which control the performance of the left ventricle include the determinants of myocardial function (preload, afterload, contractility and heart rate) and peripheral vascular function (capacitance and impedance). Arterial pressure represents an interaction of myocardial and vascular factors. When left ventricular function becomes impaired, impedance to left ventricular ejection becomes increasingly important in determining cardiac performance. Increases in impedance may result from the influence on arteries of neural, humoral or structural changes which can occur in response to a fall in cardiac output or an impairment of cardiac reserve. This increased impedance may further reduce cardiac output while myocardial oxygen consumption is increased. Alterations in the peripheral vascular bed therefore probably play an important role in the hemodynamic and metabolic events which usually are attributed to progressive impairment of the heart. Pharmacologie reduction of impedance with vasodilator drugs could become an important adjunct in the management of heart failure of diverse etiologies.",
author = "Cohn, {Jay N}",
year = "1973",
month = "9",
doi = "10.1016/0002-9343(73)90135-6",
language = "English (US)",
volume = "55",
pages = "351--361",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Blood pressure and cardiac performance

AU - Cohn, Jay N

PY - 1973/9

Y1 - 1973/9

N2 - The factors which control the performance of the left ventricle include the determinants of myocardial function (preload, afterload, contractility and heart rate) and peripheral vascular function (capacitance and impedance). Arterial pressure represents an interaction of myocardial and vascular factors. When left ventricular function becomes impaired, impedance to left ventricular ejection becomes increasingly important in determining cardiac performance. Increases in impedance may result from the influence on arteries of neural, humoral or structural changes which can occur in response to a fall in cardiac output or an impairment of cardiac reserve. This increased impedance may further reduce cardiac output while myocardial oxygen consumption is increased. Alterations in the peripheral vascular bed therefore probably play an important role in the hemodynamic and metabolic events which usually are attributed to progressive impairment of the heart. Pharmacologie reduction of impedance with vasodilator drugs could become an important adjunct in the management of heart failure of diverse etiologies.

AB - The factors which control the performance of the left ventricle include the determinants of myocardial function (preload, afterload, contractility and heart rate) and peripheral vascular function (capacitance and impedance). Arterial pressure represents an interaction of myocardial and vascular factors. When left ventricular function becomes impaired, impedance to left ventricular ejection becomes increasingly important in determining cardiac performance. Increases in impedance may result from the influence on arteries of neural, humoral or structural changes which can occur in response to a fall in cardiac output or an impairment of cardiac reserve. This increased impedance may further reduce cardiac output while myocardial oxygen consumption is increased. Alterations in the peripheral vascular bed therefore probably play an important role in the hemodynamic and metabolic events which usually are attributed to progressive impairment of the heart. Pharmacologie reduction of impedance with vasodilator drugs could become an important adjunct in the management of heart failure of diverse etiologies.

UR - http://www.scopus.com/inward/record.url?scp=0015895413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015895413&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(73)90135-6

DO - 10.1016/0002-9343(73)90135-6

M3 - Article

C2 - 4746558

AN - SCOPUS:0015895413

VL - 55

SP - 351

EP - 361

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 3

ER -