Blood-Group Antibodies in Human Immune Serum Globulin

Phillip Niosi, Janet Lundberg, Jeffrey Mccullough, B. H. Park, D. W. Biggar

Research output: Contribution to journalLetterpeer-review

22 Scopus citations


To the Editor: Human immune serum (gamma) globulin is prepared commercially in the United States by Cohn's method (cold ethanol fractionation) from pooled normal plasma or from placental blood. The only requirements for its licensure are that the final product must contain 16.5 ± 1.5 g per 100 ml of globulin and that 90 per cent of this protein must be of a defined electrophoretic mobility.1 These are minimum standards for potency, but apparently there are no standards concerning the maximum amount of other materials such as blood-group antibodies in the immune-serum-globulin preparations. The following case illustrates that such blood-group.

Original languageEnglish (US)
Pages (from-to)1435-1436
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - Dec 16 1971
Externally publishedYes


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