Blockage of Lysosomal Degradation Is Detrimental to Cancer Cell Survival: Role of Autophagy Activation

Keyphrases

• Acidic Organelle 25%
• Antiestrogen 25%
• Autophagic Cargo 25%
• Autophagic Vacuoles 25%
• Autophagy 100%
• Autophagy Pathway 100%
• BH3 Mimetics 25%
• Blockage 100%
• Breast Cancer 25%
• Breast Cancer Cells 25%
• Cancer Cell Survival 100%
• Cancer Cells 100%
• Cancer Patients 25%
• Cancer Progression 25%
• Catabolic Activity 25%
• Cathepsin 75%
• Cathepsin D 25%
• Cathepsin L 25%
• Cell Death 25%
• Cell Density 25%
• Cell Progression 25%
• Cellular Compartments 25%
• Damaged Organelles 25%
• Damaged Proteins 25%
• Death Pathway 25%
• Homeostasis 25%
• Hydrolases 25%
• Hydrolytic 25%
• Improved Outcomes 25%
• Lysosomal Degradation 100%
• Lysosomal Function 50%
• Lysosomal Membrane 25%
• Lysosomal Membrane Permeabilization 25%
• Lysosome 50%
• Neoplastic Transformation 25%
• Obatoclax 50%
• Pro-oncogenic 25%
• Protease 25%
• Protease Activity 25%
• Protein Expression 25%
• Resistant Breast Cancer 25%
• Subsequent Cancer 25%
• Volume Activity 25%
• Volume Number 25%

Biochemistry, Genetics and Molecular Biology

• Autophagy 100%
• Cancer Cell 100%
• Cathepsin 50%
• Cathepsin D 16%
• Cathepsin L 16%
• Cell Death 16%
• Cell Density 16%
• Cell Survival 100%
• Homeostasis 16%
• Hydrolase 16%
• Lysosome 33%
• Protease 33%
• Protein Expression 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Antiestrogen 16%
• Breast Cancer 33%
• Cancer Growth 16%
• Cathepsin 50%
• Cathepsin D 16%
• Cathepsin L 16%
• Hydrolase 16%
• Malignant Neoplasm 100%
• Obatoclax 33%
• Proteinase 33%