Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL

Hrishikesh K. Srinagesh; Vishal Gupta; Amy Zhang; Michael Grunwald; Matthew Connor; Vamsi K. Kota; Jacob Boccucci; Matthew Ulrickson; Roshini Pradeep; La Quisa Hill; Stephanie B. Tsai; Timothy O'Connor; Karamjeet Sandhu; Anjali S. Advani; Ran Reshef; Christian A. Gordillo; Marlise R. Luskin; Evan C. Chen; Chenyu Lin; Ryan D. Cassaday; Noam E. Kopmar; Navneet S. Majhail; Minoo Battiwalla; Stephen A. Strickland; Catherine J. Lee; Silvina Odstrcil Bobillo; Talal Hilal; Jae H. Park; Yannis K. Valtis; Rawan Faramand; Melhem M. Solh; Caitlin Guzowski; Sumithira Vasu; Jessica T. Leonard; Virginia Tan; Eunice S. Wang; Ross McCauley; Joshua Sasine; Kevin Tang; Katharine Miller; Katherine C. Sutherland; Michael Daunov; Razan Mohty; Omer Jamy; Muthu V. Kumaran; Rasmus T. Hoeg; Kaitlyn C. Dykes; Aaron C. Logan; Tamer Othman; Wendy Stock; Marc Schwartz; Kenneth Byrd; Fevzi Yalniz; Veronika Bachanova; Sean Tracy; George Yaghmour; Vivian M. Irizarry Gatell; Clayton W. Jackson; Olalekan O. Oluwole; Bhagirathbhai Dholaria; Kristen M. O'Dwyer; Jozal Moore; Gregory W. Roloff; Noelle V. Frey; Ibrahim Aldoss; Bijal D. Shah; Caspian H. Oliai; Lori S. Muffly

doi:10.1182/blood.2025031734

Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL

Hrishikesh K. Srinagesh
, Vishal Gupta
, Amy Zhang
, Michael Grunwald
, Matthew Connor
, Vamsi K. Kota
, Jacob Boccucci
, Matthew Ulrickson
, Roshini Pradeep
, La Quisa Hill
, Stephanie B. Tsai
, Timothy O'Connor
, Karamjeet Sandhu
, Anjali S. Advani
, Ran Reshef
, Christian A. Gordillo
, Marlise R. Luskin
, Evan C. Chen
, Chenyu Lin
, Ryan D. Cassaday

Noam E. Kopmar, Navneet S. Majhail, Minoo Battiwalla, Stephen A. Strickland, Catherine J. Lee, Silvina Odstrcil Bobillo, Talal Hilal, Jae H. Park, Yannis K. Valtis, Rawan Faramand, Melhem M. Solh, Caitlin Guzowski, Sumithira Vasu, Jessica T. Leonard, Virginia Tan, Eunice S. Wang, Ross McCauley, Joshua Sasine, Kevin Tang, Katharine Miller, Katherine C. Sutherland, Michael Daunov, Razan Mohty, Omer Jamy, Muthu V. Kumaran, Rasmus T. Hoeg, Kaitlyn C. Dykes, Aaron C. Logan, Tamer Othman, Wendy Stock, Marc Schwartz, Kenneth Byrd, Fevzi Yalniz, Veronika Bachanova, Sean Tracy, George Yaghmour, Vivian M. Irizarry Gatell, Clayton W. Jackson, Olalekan O. Oluwole, Bhagirathbhai Dholaria, Kristen M. O'Dwyer, Jozal Moore, Gregory W. Roloff, Noelle V. Frey, Ibrahim Aldoss, Bijal D. Shah, Caspian H. Oliai, Lori S. Muffly

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In a real-world analysis of brexucabtagene autoleucel recipients with relapsed/refractory B-cell acute lymphoblastic leukemia (N = 278), lack of response to prior blinatumomab correlates with significantly worse following chimeric antigen receptor T-cell therapy outcomes.

Original language	English (US)
Pages (from-to)	2011-2017
Number of pages	7
Journal	Blood
Volume	147
Issue number	17
DOIs	https://doi.org/10.1182/blood.2025031734
State	Published - Apr 23 2026

Bibliographical note

Publisher Copyright:
© 2026 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1182/blood.2025031734

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Srinagesh, H. K., Gupta, V., Zhang, A., Grunwald, M., Connor, M., Kota, V. K., Boccucci, J., Ulrickson, M., Pradeep, R., Hill, L. Q., Tsai, S. B., O'Connor, T., Sandhu, K., Advani, A. S., Reshef, R., Gordillo, C. A., Luskin, M. R., Chen, E. C., Lin, C., ... Muffly, L. S. (2026). Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL. Blood, 147(17), 2011-2017. https://doi.org/10.1182/blood.2025031734

Srinagesh, HK, Gupta, V, Zhang, A, Grunwald, M, Connor, M, Kota, VK, Boccucci, J, Ulrickson, M, Pradeep, R, Hill, LQ, Tsai, SB, O'Connor, T, Sandhu, K, Advani, AS, Reshef, R, Gordillo, CA, Luskin, MR, Chen, EC, Lin, C, Cassaday, RD, Kopmar, NE, Majhail, NS, Battiwalla, M, Strickland, SA, Lee, CJ, Bobillo, SO, Hilal, T, Park, JH, Valtis, YK, Faramand, R, Solh, MM, Guzowski, C, Vasu, S, Leonard, JT, Tan, V, Wang, ES, McCauley, R, Sasine, J, Tang, K, Miller, K, Sutherland, KC, Daunov, M, Mohty, R, Jamy, O, Kumaran, MV, Hoeg, RT, Dykes, KC, Logan, AC, Othman, T, Stock, W, Schwartz, M, Byrd, K, Yalniz, F, Bachanova, V , Tracy, S, Yaghmour, G, Irizarry Gatell, VM, Jackson, CW, Oluwole, OO, Dholaria, B, O'Dwyer, KM, Moore, J, Roloff, GW, Frey, NV, Aldoss, I, Shah, BD, Oliai, CH & Muffly, LS 2026, 'Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL', Blood, vol. 147, no. 17, pp. 2011-2017. https://doi.org/10.1182/blood.2025031734

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title = "Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL",

abstract = "In a real-world analysis of brexucabtagene autoleucel recipients with relapsed/refractory B-cell acute lymphoblastic leukemia (N = 278), lack of response to prior blinatumomab correlates with significantly worse following chimeric antigen receptor T-cell therapy outcomes.",

author = "Srinagesh, \{Hrishikesh K.\} and Vishal Gupta and Amy Zhang and Michael Grunwald and Matthew Connor and Kota, \{Vamsi K.\} and Jacob Boccucci and Matthew Ulrickson and Roshini Pradeep and Hill, \{La Quisa\} and Tsai, \{Stephanie B.\} and Timothy O'Connor and Karamjeet Sandhu and Advani, \{Anjali S.\} and Ran Reshef and Gordillo, \{Christian A.\} and Luskin, \{Marlise R.\} and Chen, \{Evan C.\} and Chenyu Lin and Cassaday, \{Ryan D.\} and Kopmar, \{Noam E.\} and Majhail, \{Navneet S.\} and Minoo Battiwalla and Strickland, \{Stephen A.\} and Lee, \{Catherine J.\} and Bobillo, \{Silvina Odstrcil\} and Talal Hilal and Park, \{Jae H.\} and Valtis, \{Yannis K.\} and Rawan Faramand and Solh, \{Melhem M.\} and Caitlin Guzowski and Sumithira Vasu and Leonard, \{Jessica T.\} and Virginia Tan and Wang, \{Eunice S.\} and Ross McCauley and Joshua Sasine and Kevin Tang and Katharine Miller and Sutherland, \{Katherine C.\} and Michael Daunov and Razan Mohty and Omer Jamy and Kumaran, \{Muthu V.\} and Hoeg, \{Rasmus T.\} and Dykes, \{Kaitlyn C.\} and Logan, \{Aaron C.\} and Tamer Othman and Wendy Stock and Marc Schwartz and Kenneth Byrd and Fevzi Yalniz and Veronika Bachanova and Sean Tracy and George Yaghmour and \{Irizarry Gatell\}, \{Vivian M.\} and Jackson, \{Clayton W.\} and Oluwole, \{Olalekan O.\} and Bhagirathbhai Dholaria and O'Dwyer, \{Kristen M.\} and Jozal Moore and Roloff, \{Gregory W.\} and Frey, \{Noelle V.\} and Ibrahim Aldoss and Shah, \{Bijal D.\} and Oliai, \{Caspian H.\} and Muffly, \{Lori S.\}",

note = "Publisher Copyright: {\textcopyright} 2026 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",

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month = apr,

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doi = "10.1182/blood.2025031734",

language = "English (US)",

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AU - Srinagesh, Hrishikesh K.

AU - Gupta, Vishal

AU - Zhang, Amy

AU - Grunwald, Michael

AU - Connor, Matthew

AU - Kota, Vamsi K.

AU - Boccucci, Jacob

AU - Ulrickson, Matthew

AU - Pradeep, Roshini

AU - Hill, La Quisa

AU - Tsai, Stephanie B.

AU - O'Connor, Timothy

AU - Sandhu, Karamjeet

AU - Advani, Anjali S.

AU - Reshef, Ran

AU - Gordillo, Christian A.

AU - Luskin, Marlise R.

AU - Chen, Evan C.

AU - Lin, Chenyu

AU - Cassaday, Ryan D.

AU - Kopmar, Noam E.

AU - Majhail, Navneet S.

AU - Battiwalla, Minoo

AU - Strickland, Stephen A.

AU - Lee, Catherine J.

AU - Bobillo, Silvina Odstrcil

AU - Hilal, Talal

AU - Park, Jae H.

AU - Valtis, Yannis K.

AU - Faramand, Rawan

AU - Solh, Melhem M.

AU - Guzowski, Caitlin

AU - Vasu, Sumithira

AU - Leonard, Jessica T.

AU - Tan, Virginia

AU - Wang, Eunice S.

AU - McCauley, Ross

AU - Sasine, Joshua

AU - Tang, Kevin

AU - Miller, Katharine

AU - Sutherland, Katherine C.

AU - Daunov, Michael

AU - Mohty, Razan

AU - Jamy, Omer

AU - Kumaran, Muthu V.

AU - Hoeg, Rasmus T.

AU - Dykes, Kaitlyn C.

AU - Logan, Aaron C.

AU - Othman, Tamer

AU - Stock, Wendy

AU - Schwartz, Marc

AU - Byrd, Kenneth

AU - Yalniz, Fevzi

AU - Bachanova, Veronika

AU - Tracy, Sean

AU - Yaghmour, George

AU - Irizarry Gatell, Vivian M.

AU - Jackson, Clayton W.

AU - Oluwole, Olalekan O.

AU - Dholaria, Bhagirathbhai

AU - O'Dwyer, Kristen M.

AU - Moore, Jozal

AU - Roloff, Gregory W.

AU - Frey, Noelle V.

AU - Aldoss, Ibrahim

AU - Shah, Bijal D.

AU - Oliai, Caspian H.

AU - Muffly, Lori S.

PY - 2026/4/23

Y1 - 2026/4/23

N2 - In a real-world analysis of brexucabtagene autoleucel recipients with relapsed/refractory B-cell acute lymphoblastic leukemia (N = 278), lack of response to prior blinatumomab correlates with significantly worse following chimeric antigen receptor T-cell therapy outcomes.

AB - In a real-world analysis of brexucabtagene autoleucel recipients with relapsed/refractory B-cell acute lymphoblastic leukemia (N = 278), lack of response to prior blinatumomab correlates with significantly worse following chimeric antigen receptor T-cell therapy outcomes.

UR - https://www.scopus.com/pages/publications/105032082355

UR - https://www.scopus.com/pages/publications/105032082355#tab=citedBy

U2 - 10.1182/blood.2025031734

DO - 10.1182/blood.2025031734

M3 - Article

C2 - 41643192

AN - SCOPUS:105032082355

SN - 0006-4971

VL - 147

SP - 2011

EP - 2017

JO - Blood

JF - Blood

IS - 17

ER -

Blinatumomab nonresponse correlates with poor survival after brexucabtagene autoleucel in B-cell ALL

Abstract

Bibliographical note

UN SDGs

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