Blastomycosis in immunosuppressed patients

L. D. Recht, S. F. Davies, M. R. Eckman, G. A. Sarosi

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Of 78 patients with blastomycosis, 3 patients had received glucocorticoid therapy prior to diagnosis and 3 others had an underlying hematologic malignancy (chronic lymphocytic prior to diagnosis and 3 others had an underlying hematologic malignancy (chronic lymphocytic leukemia, chronic myelogenous leukemia, multiple myeloma). The clinical picture in these 6 patients was similar to blastomycosis in nonimmunosuppressed patients (in contrast to histoplasmosis or coccidioidomycosis in immunosuppressed patients in whom a distinct clinical syndrome is often seen). The patients presented with chronic pulmonary infiltrates or with isolated skin ulcers. The response to therapy was good if the diagnosis was made early. Blastomycosis can occur in immunosuppressed patients. However, the spectrum of underlying illness is not that seen in opportunistic histoplasmosis or coccidioidomycosis, where patients with T-cell defects predominate. Possible explanations for the rarity of blastomycosis in more classically T-cell-immunosuppressed patients are discussed.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalAmerican Review of Respiratory Disease
Volume125
Issue number3 I
StatePublished - Jan 1 1982

Fingerprint Dive into the research topics of 'Blastomycosis in immunosuppressed patients'. Together they form a unique fingerprint.

  • Cite this

    Recht, L. D., Davies, S. F., Eckman, M. R., & Sarosi, G. A. (1982). Blastomycosis in immunosuppressed patients. American Review of Respiratory Disease, 125(3 I), 359-362.