Blastocyst complementation and interspecies chimeras in gene edited pigs

Research output: Contribution to journalShort surveypeer-review


The only curative therapy for many endstage diseases is allograft organ transplantation. Due to the limited supply of donor organs, relatively few patients are recipients of a transplanted organ. Therefore, new strategies are warranted to address this unmet need. Using gene editing technologies, somatic cell nuclear transfer and human induced pluripotent stem cell technologies, interspecies chimeric organs have been pursued with promising results. In this review, we highlight the overall technical strategy, the successful early results and the hurdles that need to be addressed in order for these approaches to produce a successful organ that could be transplanted in patients with endstage diseases.

Original languageEnglish (US)
Article number1065536
JournalFrontiers in Cell and Developmental Biology
StatePublished - Dec 8 2022

Bibliographical note

Funding Information:
This work was supported by the NIH (HL144582 and HL160476), RMM (101617-DS-003) and DOD. The authors acknowledge the efforts of Cynthia Faraday for figure preparation.

Publisher Copyright:
Copyright © 2022 Choe, Sorensen, Garry and Garry.


  • ETV2
  • MYF6
  • Myf5
  • MyoD
  • blastocyst complementation
  • pigs
  • somatic cell nuclear transfer

PubMed: MeSH publication types

  • Journal Article
  • Review


Dive into the research topics of 'Blastocyst complementation and interspecies chimeras in gene edited pigs'. Together they form a unique fingerprint.

Cite this