Blastic Indeterminate Dendritic Cell Tumor Associated With Chronic Myelomonocytic Leukemia

Austin Ellis, Ismail Elbaz Younes, Haipeng Shao, Xiaohui Zhang

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Indeterminate dendritic cell tumor (IDCT) is an exceedingly rare neoplasm that can be associated with hematopoietic malignancies. We report a case of multifocal cutaneous blastic indeterminate dendritic cell tumor (BIDCT) in a 75-year-old man with chronic myelomonocytic leukemia showing blastic histiocytoid morphology, positivity for CD1a and S100, and no expression of langerin. We present a literature review on the 11 reported cases of IDCTs/BIDCTs associated with chronic myelomonocytic leukemia (CMML), including this case. The clinicopathological characteristics have been summarized. The IDCT and CMML cells are clonally related in 4 tested cases. Patients with IDCT/BIDCT associated with CMML seem to have worse clinical outcomes compared with patients with IDCT not associated with CMML.

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalAmerican Journal of Dermatopathology
Issue number9
StatePublished - Sep 1 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.


  • chronic myelomonocytic leukemia
  • histiocytic/dendritic cell tumor
  • indeterminate dendritic cell tumor
  • leukemia cutis

PubMed: MeSH publication types

  • Case Reports
  • Journal Article
  • Review


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