Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric Mechanism

Keyphrases

• Substrate Binding 100%
• ATP Binding 100%
• Bitopic 100%
• Allosteric Mechanism 100%
• Protein Kinase 66%
• Switch Region 66%
• ATP Binding Site 66%
• Allosteric Switch 66%
• Small Molecule Inhibitors 33%
• Dynamic Interaction 33%
• Conformational Dynamics 33%
• Dynamic Mechanism 33%
• Lack of Understanding 33%
• Conformational Flexibility 33%
• Binding Interface 33%
• ATP-competitive 33%
• Staurosporine Analog 33%
• Conserved Mechanisms 33%
• All-atom Molecular Dynamics Simulation 33%
• Nucleotide Binding 33%
• Activation Loop 33%
• Bitopic Ligands 33%
• DFG Motif 33%
• Selective Phosphorylation 33%
• FRET Sensor 33%
• G-loop 33%

Biochemistry, Genetics and Molecular Biology

• Adenosine Triphosphate 100%
• Binding Site 50%
• Phosphotransferase 50%
• Kinase 50%
• Fluorescence Resonance Energy Transfer 25%
• Small Molecule 25%
• Staurosporine 25%
• Protein Kinases 25%
• Protein Kinase C 25%