[Bis(2-methoxyethyl)amino]sulfur Trifluoride, the Deoxo-Fluor Reagent: Application toward One-Flask Transformations of Carboxylic Acids to Amides

Jonathan M. White, Ashok Rao Tunoori, Brandon J. Turunen, Gunda I. Georg

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The use of the Deoxo-Fluor reagent is a versatile method for acyl fluoride generation and subsequent one-flask amide coupling. It provides mild conditions and facile purification of the desired products in good to excellent yields. We have explored the utility of this reagent for the one-flask conversion of acids to amides and Weinreb amides and as a peptide-coupling reagent.

Original languageEnglish (US)
Pages (from-to)2573-2576
Number of pages4
JournalJournal of Organic Chemistry
Volume69
Issue number7
DOIs
StatePublished - Apr 2 2004

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