Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)

Xiao Ou Shu; Dehui Han; Richard K. Severson; Zhi Chen; Joseph P. Neglia; Gregory H. Reaman; Jonathan D. Buckley; Leslie L. Robison

doi:10.1023/A:1013986809917

Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)

Xiao Ou Shu, Dehui Han, Richard K. Severson, Zhi Chen, Joseph P. Neglia, Gregory H. Reaman, Jonathan D. Buckley, Leslie L. Robison

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Objective: To investigate the associations of birth characteristics and maternal reproductive factors with risk of childhood acute lymphoblastic leukemia (ALL) by immunophenotypic subtypes. Methods: Data collected from a case-control study including 1842 ALL cases (age < 15 years) and 1986 individually matched controls were analyzed. Exposure information was obtained through telephone interviews of parents. Results: Factors associated with risk of ALL from all subgroups combined included high birth weight (OR = 1.4, 95% CI = 1.1-1.8), high birth order (OR = 2.0, 95% CI = 1.3-3.0 for fourth-born child compared to first-born child), young maternal age (<20 compared to 25-29, OR = 1.4, 95% CI = 1.1-1.9), advanced paternal age (> 39 compared to 25-29, OR = 1.4, 95% CI = 1.0-1.9), induced abortion prior to the index pregnancy (OR = 1.2, 95% CI = 1.0-1.4), and oral contraceptive use during the index pregnancy (OR = 1.5, 95% CI = 1.0-2.2) with children under the age of 2 (OR = 5.1, 95% CI = 1.0-24.7) being the predominantly affected group. Risk of early pre-B-cell ALL increased with advanced paternal age (OR = 1.7, 95% CI = 1.1-2.7) and high birth order (OR = 2.0, 95% CI = 1.1-3.6), while risk of pre-B-cell ALL increased with both younger (OR= 3.4, 95% CI = 1.4-8.4) and advanced maternal age (OR =2.6, 95% CI = 1.1-5.9). T-cell ALL was associated with high birth weight (OR = 2.4, 95% CI = 1.1-5.5) and history of induced abortion (OR =2.4, 95% CI = 1.3-4.5). Conclusion: This study suggests that the association of ALL with birth characteristics and maternal reproductive factors varies with the immunophenotype of the ALL. Future studies are needed to better understand the effect of maternal hormone in the development of subtype of childhood ALL.

Original language	English (US)
Pages (from-to)	15-25
Number of pages	11
Journal	Cancer Causes and Control
Volume	13
Issue number	1
DOIs	https://doi.org/10.1023/A:1013986809917
State	Published - 2002

Bibliographical note

Funding Information:
This research was sponsored in part by the University of Minnesota Children’s Research Fund and grants no. CA49450 and CA58051 from the National Cancer Institute. Participating Children’s Cancer Group investigators, institutions, and grant numbers (Division of Cancer Treatment, National Cancer Institute) are provided in the appendix.

Keywords

ALL
Birth characteristics
Oral contraceptive

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1023/A:1013986809917

Find It

Find It at U of M Libraries

Cite this

@article{a09ff12935d8401fa60572412eb74092,

title = "Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)",

abstract = "Objective: To investigate the associations of birth characteristics and maternal reproductive factors with risk of childhood acute lymphoblastic leukemia (ALL) by immunophenotypic subtypes. Methods: Data collected from a case-control study including 1842 ALL cases (age < 15 years) and 1986 individually matched controls were analyzed. Exposure information was obtained through telephone interviews of parents. Results: Factors associated with risk of ALL from all subgroups combined included high birth weight (OR = 1.4, 95% CI = 1.1-1.8), high birth order (OR = 2.0, 95% CI = 1.3-3.0 for fourth-born child compared to first-born child), young maternal age (<20 compared to 25-29, OR = 1.4, 95% CI = 1.1-1.9), advanced paternal age (> 39 compared to 25-29, OR = 1.4, 95% CI = 1.0-1.9), induced abortion prior to the index pregnancy (OR = 1.2, 95% CI = 1.0-1.4), and oral contraceptive use during the index pregnancy (OR = 1.5, 95% CI = 1.0-2.2) with children under the age of 2 (OR = 5.1, 95% CI = 1.0-24.7) being the predominantly affected group. Risk of early pre-B-cell ALL increased with advanced paternal age (OR = 1.7, 95% CI = 1.1-2.7) and high birth order (OR = 2.0, 95% CI = 1.1-3.6), while risk of pre-B-cell ALL increased with both younger (OR= 3.4, 95% CI = 1.4-8.4) and advanced maternal age (OR =2.6, 95% CI = 1.1-5.9). T-cell ALL was associated with high birth weight (OR = 2.4, 95% CI = 1.1-5.5) and history of induced abortion (OR =2.4, 95% CI = 1.3-4.5). Conclusion: This study suggests that the association of ALL with birth characteristics and maternal reproductive factors varies with the immunophenotype of the ALL. Future studies are needed to better understand the effect of maternal hormone in the development of subtype of childhood ALL.",

keywords = "ALL, Birth characteristics, Oral contraceptive",

author = "{Ou Shu}, Xiao and Dehui Han and Severson, {Richard K.} and Zhi Chen and Neglia, {Joseph P.} and Reaman, {Gregory H.} and Buckley, {Jonathan D.} and Robison, {Leslie L.}",

note = "Funding Information: This research was sponsored in part by the University of Minnesota Children{\textquoteright}s Research Fund and grants no. CA49450 and CA58051 from the National Cancer Institute. Participating Children{\textquoteright}s Cancer Group investigators, institutions, and grant numbers (Division of Cancer Treatment, National Cancer Institute) are provided in the appendix.",

year = "2002",

doi = "10.1023/A:1013986809917",

language = "English (US)",

volume = "13",

pages = "15--25",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Netherlands",

number = "1",

}

TY - JOUR

T1 - Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)

AU - Ou Shu, Xiao

AU - Han, Dehui

AU - Severson, Richard K.

AU - Chen, Zhi

AU - Neglia, Joseph P.

AU - Reaman, Gregory H.

AU - Buckley, Jonathan D.

AU - Robison, Leslie L.

N1 - Funding Information: This research was sponsored in part by the University of Minnesota Children’s Research Fund and grants no. CA49450 and CA58051 from the National Cancer Institute. Participating Children’s Cancer Group investigators, institutions, and grant numbers (Division of Cancer Treatment, National Cancer Institute) are provided in the appendix.

PY - 2002

Y1 - 2002

N2 - Objective: To investigate the associations of birth characteristics and maternal reproductive factors with risk of childhood acute lymphoblastic leukemia (ALL) by immunophenotypic subtypes. Methods: Data collected from a case-control study including 1842 ALL cases (age < 15 years) and 1986 individually matched controls were analyzed. Exposure information was obtained through telephone interviews of parents. Results: Factors associated with risk of ALL from all subgroups combined included high birth weight (OR = 1.4, 95% CI = 1.1-1.8), high birth order (OR = 2.0, 95% CI = 1.3-3.0 for fourth-born child compared to first-born child), young maternal age (<20 compared to 25-29, OR = 1.4, 95% CI = 1.1-1.9), advanced paternal age (> 39 compared to 25-29, OR = 1.4, 95% CI = 1.0-1.9), induced abortion prior to the index pregnancy (OR = 1.2, 95% CI = 1.0-1.4), and oral contraceptive use during the index pregnancy (OR = 1.5, 95% CI = 1.0-2.2) with children under the age of 2 (OR = 5.1, 95% CI = 1.0-24.7) being the predominantly affected group. Risk of early pre-B-cell ALL increased with advanced paternal age (OR = 1.7, 95% CI = 1.1-2.7) and high birth order (OR = 2.0, 95% CI = 1.1-3.6), while risk of pre-B-cell ALL increased with both younger (OR= 3.4, 95% CI = 1.4-8.4) and advanced maternal age (OR =2.6, 95% CI = 1.1-5.9). T-cell ALL was associated with high birth weight (OR = 2.4, 95% CI = 1.1-5.5) and history of induced abortion (OR =2.4, 95% CI = 1.3-4.5). Conclusion: This study suggests that the association of ALL with birth characteristics and maternal reproductive factors varies with the immunophenotype of the ALL. Future studies are needed to better understand the effect of maternal hormone in the development of subtype of childhood ALL.

AB - Objective: To investigate the associations of birth characteristics and maternal reproductive factors with risk of childhood acute lymphoblastic leukemia (ALL) by immunophenotypic subtypes. Methods: Data collected from a case-control study including 1842 ALL cases (age < 15 years) and 1986 individually matched controls were analyzed. Exposure information was obtained through telephone interviews of parents. Results: Factors associated with risk of ALL from all subgroups combined included high birth weight (OR = 1.4, 95% CI = 1.1-1.8), high birth order (OR = 2.0, 95% CI = 1.3-3.0 for fourth-born child compared to first-born child), young maternal age (<20 compared to 25-29, OR = 1.4, 95% CI = 1.1-1.9), advanced paternal age (> 39 compared to 25-29, OR = 1.4, 95% CI = 1.0-1.9), induced abortion prior to the index pregnancy (OR = 1.2, 95% CI = 1.0-1.4), and oral contraceptive use during the index pregnancy (OR = 1.5, 95% CI = 1.0-2.2) with children under the age of 2 (OR = 5.1, 95% CI = 1.0-24.7) being the predominantly affected group. Risk of early pre-B-cell ALL increased with advanced paternal age (OR = 1.7, 95% CI = 1.1-2.7) and high birth order (OR = 2.0, 95% CI = 1.1-3.6), while risk of pre-B-cell ALL increased with both younger (OR= 3.4, 95% CI = 1.4-8.4) and advanced maternal age (OR =2.6, 95% CI = 1.1-5.9). T-cell ALL was associated with high birth weight (OR = 2.4, 95% CI = 1.1-5.5) and history of induced abortion (OR =2.4, 95% CI = 1.3-4.5). Conclusion: This study suggests that the association of ALL with birth characteristics and maternal reproductive factors varies with the immunophenotype of the ALL. Future studies are needed to better understand the effect of maternal hormone in the development of subtype of childhood ALL.

KW - ALL

KW - Birth characteristics

KW - Oral contraceptive

UR - http://www.scopus.com/inward/record.url?scp=0036173064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036173064&partnerID=8YFLogxK

U2 - 10.1023/A:1013986809917

DO - 10.1023/A:1013986809917

M3 - Article

C2 - 11899114

AN - SCOPUS:0036173064

SN - 0957-5243

VL - 13

SP - 15

EP - 25

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 1

ER -

Birth characteristics, maternal reproductive history, hormone use during pregnancy, and risk of childhood acute lymphocytic leukemia by immunophenotype (United States)

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this