Biotransformation of the fungicide pentachloronitrobenzene by Tetrahymena thermophila

Sharon E. Murphy, Anna Marie Drotar, Ray Fall

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The protozoan, Tetrahymena thermophila, metabolizes pentachloronitrobenzene to several products, including nitrite, pentachlorothioanisole and pentachloroaniline. The latter two metabolites were identified by gas chromatographymass spectrometry. Pentachlorothioanisole may be produced via a glutathione-dependent pathway, and two key enzymes of this pathway, glutathione transferase and thiol S-methyltransferase, have been detected in crude extracts of this microorganism.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
Issue number1
StatePublished - 1982
Externally publishedYes

Bibliographical note

Funding Information:
We thank Dr. Robert Barkley for running was supported by grants from the University Creative Work, and the National Institutes the GC-MS analyses. of Colorado Council of Health (ES 02639).


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