Biotemplated synthesis of metallic nanoparticle chains on an α-synuclein fiber scaffold

R. Colby, J. Hulleman, S. Padalkar, J. C. Rochet, L. A. Stanciu

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Biomolecular templates provide an excellent potential tool for bottom-up device fabrication. Self-assembling α-synuclein protein fibrils, the formation of which has been linked to Parkinson's disease, have yet to be explored for potential device fabrication. In this paper, α-synuclein fibrils were used as a template for palladium (Pd), gold (Au) and copper (Cu) nanoparticle chains synthesis. Deposition over a range of conditions resulted in metal-coated fibers with reproducible average diameters between 50 and 200 nm. Active elemental palladium deposited on the protein fibrils is used as a catalyst for the electroless deposition of Au and Cu. Nanoparticle chains were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray energy dispersive spectrometry (XEDS), and electron energy loss spectrometry (EELS).

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Issue number2
StatePublished - Feb 2008
Externally publishedYes


  • Amyloid
  • Electroless deposition
  • Nanoparticles
  • Nanowires


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