Biotechnological applications of quorum quenching enzymes

Janek Bzdrenga, David Daudé, Benjamin Rémy, Pauline Jacquet, Laure Plener, Mikael Elias, Eric Chabrière

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


Numerous bacteria use quorum sensing (QS) to synchronize their behavior and monitor their population density. They use signaling molecules known as autoinducers (AI's) that are synthesized and secreted into their local environment to regulate QS-dependent gene expression. Among QS-regulated pathways, biofilm formation and virulence factor secretion are particularly problematic as they are involved in surface-attachment, antimicrobial agent resistance, toxicity, and pathogenicity. Targeting QS represents a promising strategy to inhibit undesirable bacterial traits. This strategy, referred to as quorum quenching (QQ), includes QS-inhibitors and QQ enzymes. These approaches are appealing because they do not directly challenge bacterial survival, and consequently selection pressure may be low, yielding a lower occurrence of resistance. QQ enzymes are particularly promising because they act extracellularly to degrade AI's and can be used in catalytic quantities. This review draws an overview of QQ enzyme related applications, covering several economically important fields such as agriculture, aquaculture, biofouling and health issues. Finally, the possibility of resistance mechanism occurrence to QQ strategies is discussed.

Original languageEnglish (US)
Pages (from-to)104-115
Number of pages12
JournalChemico-Biological Interactions
StatePublished - Apr 1 2017

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ireland Ltd


  • Biofilm
  • Enzyme
  • Lactonase
  • Quorum quenching
  • Quorum sensing
  • Virulence


Dive into the research topics of 'Biotechnological applications of quorum quenching enzymes'. Together they form a unique fingerprint.

Cite this