Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain

U. Hornemann; L. H. Hurley; M. K. Speedie; H. F. Guenther; H. G. Floss

doi:10.1039/C29690000245

Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain

U. Hornemann
, L. H. Hurley
, M. K. Speedie
, H. F. Guenther
, H. G. Floss

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Original language	English (US)
Pages (from-to)	245-246
Number of pages	2
Journal	Journal of the Chemical Society D: Chemical Communications
Issue number	6
DOIs	https://doi.org/10.1039/C29690000245
State	Published - 1969

Bibliographical note

Funding Information:
This compound could be formed from tryptophan by transamination and methylation. We thank Chas. Pfizer and Company for providing us with n culture of the indolymcin-producing Streptornyces grisem CHEMICALCOMMUNICATIONS, strain ATCC 12648 and for a gift of authentic indolymcin. This work was supported by National Institutes of Health grants. One of us (M. K. S.) is an N.S.F. Undergraduate Incorporatioil of Zabelled substvatesiuto i??doZ.lnycis?by Streptoi-uyccsgriseus Precursor [3H]Anthranilic acid .. .. .. [2-14C]Indole .. .. .. .. [3H]-~-Tryptophan . . *. .I [aZanine-3-l%] -DL-Tryptophan .. [aZa~zine-2-~~C] an-~~-Tryptoph ..

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title = "Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain",

author = "U. Hornemann and Hurley, \{L. H.\} and Speedie, \{M. K.\} and Guenther, \{H. F.\} and Floss, \{H. G.\}",

note = "Funding Information: This compound could be formed from tryptophan by transamination and methylation. We thank Chas. Pfizer and Company for providing us with n culture of the indolymcin-producing Streptornyces grisem CHEMICALCOMMUNICATIONS, strain ATCC 12648 and for a gift of authentic indolymcin. This work was supported by National Institutes of Health grants. One of us (M. K. S.) is an N.S.F. Undergraduate Incorporatioil of Zabelled substvatesiuto i??doZ.lnycis?by Streptoi-uyccsgriseus Precursor [3H]Anthranilic acid .. .. .. [2-14C]Indole .. .. .. .. [3H]-\textasciitilde{}-Tryptophan . . *. .I [aZanine-3-l\%] -DL-Tryptophan .. [aZa\textasciitilde{}zine-2-\textasciitilde{}\textasciitilde{}C] an-\textasciitilde{}\textasciitilde{}-Tryptoph .. ",

year = "1969",

doi = "10.1039/C29690000245",

language = "English (US)",

pages = "245--246",

journal = "Journal of the Chemical Society D: Chemical Communications",

issn = "0577-6171",

number = "6",

}

TY - JOUR

T1 - Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain

AU - Hornemann, U.

AU - Hurley, L. H.

AU - Speedie, M. K.

AU - Guenther, H. F.

AU - Floss, H. G.

N1 - Funding Information: This compound could be formed from tryptophan by transamination and methylation. We thank Chas. Pfizer and Company for providing us with n culture of the indolymcin-producing Streptornyces grisem CHEMICALCOMMUNICATIONS, strain ATCC 12648 and for a gift of authentic indolymcin. This work was supported by National Institutes of Health grants. One of us (M. K. S.) is an N.S.F. Undergraduate Incorporatioil of Zabelled substvatesiuto i??doZ.lnycis?by Streptoi-uyccsgriseus Precursor [3H]Anthranilic acid .. .. .. [2-14C]Indole .. .. .. .. [3H]-~-Tryptophan . . *. .I [aZanine-3-l%] -DL-Tryptophan .. [aZa~zine-2-~~C] an-~~-Tryptoph ..

PY - 1969

Y1 - 1969

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UR - https://www.scopus.com/pages/publications/37049140515#tab=citedBy

U2 - 10.1039/C29690000245

DO - 10.1039/C29690000245

M3 - Article

AN - SCOPUS:37049140515

SN - 0577-6171

SP - 245

EP - 246

JO - Journal of the Chemical Society D: Chemical Communications

JF - Journal of the Chemical Society D: Chemical Communications

IS - 6

ER -

Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain

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