Biosynthesis of the antibiotic indolmycin by Streptomyces griseus. C-Methylation at the β-carbon atom of the tryptophan side-chain

U. Hornemann, L. H. Hurley, M. K. Speedie, H. F. Guenther, H. G. Floss

Research output: Contribution to journalArticlepeer-review

5 Scopus citations
Original languageEnglish (US)
Pages (from-to)245-246
Number of pages2
JournalJournal of the Chemical Society D: Chemical Communications
Issue number6
DOIs
StatePublished - 1969

Bibliographical note

Funding Information:
This compound could be formed from tryptophan by transamination and methylation. We thank Chas. Pfizer and Company for providing us with n culture of the indolymcin-producing Streptornyces grisem CHEMICALCOMMUNICATIONS, strain ATCC 12648 and for a gift of authentic indolymcin. This work was supported by National Institutes of Health grants. One of us (M. K. S.) is an N.S.F. Undergraduate Incorporatioil of Zabelled substvatesiuto i??doZ.lnycis?by Streptoi-uyccsgriseus Precursor [3H]Anthranilic acid .. .. .. [2-14C]Indole .. .. .. .. [3H]-~-Tryptophan . . *. .I [aZanine-3-l%] -DL-Tryptophan .. [aZa~zine-2-~~C] an-~~-Tryptoph ..

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