Biosynthesis of statins and its potential applications

Subhagar Seramani, Aravindan Rajendran, Viruthagiri Thangavelu

Research output: Contribution to journalReview articlepeer-review

Abstract

Statins (Hypolipidemic Agents) act as an inhibitor of 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase, are the main class of drugs to reduce Low Density Lipoprotein Cholesterol (LDL-C) levels. Statins are the fungal secondary metabolites which selectively inhibit hydroxymethyl glutaryl coenzyme A reductase, the first enzyme in cholesterol biosynthesis. Various fungi have been used to produce different types of statins commercially. This review deals with the structure, biosynthesis of statins, fermentative and synthetic production of statins, and application of statins.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalAsian Journal of Microbiology, Biotechnology and Environmental Sciences
Volume10
Issue number3
StatePublished - Dec 1 2008

Keywords

  • Fermentation
  • Low Density Lipoprotein Cholesterol (LDL-C)
  • Statins

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