Biopsy and Ablation of H3K27 Glioma Using Skull-Mounted Smartframe Device: Technical Case Report

Jiri Bartek, Ali Alattar, Margret Jensdottir, Clark C Chen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Background: Clearpoint Smartframe is a magnetic resonance imaging−compatible stereotactic system often used to perform magnetic resonance imaging−guided biopsies. The system is typically mounted on the scalp through screws that pierce the skin and penetrate the outer table of the cranium. However, the frame can also be configured to be mounted directly onto the skull. Case Description: Here, we describe the clinical context well suited for a skull-mount Clearpoint Smartframe surgery. The patient suffered from a subcentimeter right parafourth ventricular contrast-enhancing lesion with hydrocephalus and underwent a right suboccipital needle biopsy followed by an occipital ventriculoperitoneal shunt. Although the hydrocephalus resolved with the ventriculoperitoneal shunt, the biopsy sample proved nondiagnostic. The patient underwent a second procedure during which the Clearpoint Smartframe was mounted onto the skull through space dissected free during the previous surgery. Diagnostic biopsy (H3K27 glioma)was performed followed by stereotactic laser ablation of the lesion. Conclusions: We describe a case in which the skull mount Clearpoint Smartframe was used to biopsy and ablate a midline H3K27 glioma.

Original languageEnglish (US)
Pages (from-to)436-441
Number of pages6
JournalWorld neurosurgery
StatePublished - Jul 2019


  • Clearpoint Smartframe
  • Glioblastoma
  • Laser interstitial thermal therapy
  • Neurosurgery
  • Skull mount
  • Stereotactic biopsy
  • Stereotactic laser ablation

PubMed: MeSH publication types

  • Journal Article
  • Case Reports
  • Technical Report


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