Biopsies of human olfactory epithelium

Bruce W. Jafek, B. Murrow, R. Michaels, D. Restrepo, M. Linschoten

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


It has been shown that olfactory epithelium can be safely biopsied from the living, intact human being. Observations of the ultrastructure of this epithelium shows changes that can then be correlated with the etiology and degree of olfactory loss, allowing a greater understanding of both normal transduction and of the pathology of dysfunction. Examples of the common forms of olfactory dysfunction are presented and discussed. Additionally, the technique will allow additional immunohistochemical and molecular study of the tissue, will increase the understanding of both normal and pathological function and should translate to new therapeutic regimens.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalChemical Senses
Issue number7
StatePublished - Sep 2002

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