Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary

Carolyn A. Fairbanks, Cristina D. Peterson

Research output: Contribution to journalArticle

Abstract

Throughout this volume we have discussed the opioid analgesics and the propensity for subjects with established chronic pain to develop opioid-induced addiction. The class of opioid analgesic compounds and pharmaceutical dosage forms include not only chemicals with similar characteristics but also some significant distinctions that can impact the ultimate pharmacological effects on both analgesia and potential for addiction. In developing and/or implementing animal models of opioid addiction in the state of chronic pain it is valuable to be cognizant of the physicochemical and pharmacological characteristics of specific opioid analgesics. The objective of this chapter is to feature biopharmaceutical aspects of a series of the most common prescription analgesics opioids.

Original languageEnglish (US)
Pages (from-to)81-107
Number of pages27
JournalAfrika Matematika
Volume17
Issue number1
DOIs
StatePublished - Nov 16 2014

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