Biopharmaceutical Considerations of Opioid Analgesics in Models of Self-Administration: Review and Summary

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Throughout this volume we have discussed the opioid analgesics and the propensity for subjects with established chronic pain to develop opioid-induced addiction. The class of opioid analgesic compounds and pharmaceutical dosage forms include not only chemicals with similar characteristics but also some significant distinctions that can impact the ultimate pharmacological effects on both analgesia and potential for addiction. In developing and/or implementing animal models of opioid addiction in the state of chronic pain it is valuable to be cognizant of the physicochemical and pharmacological characteristics of specific opioid analgesics. The objective of this chapter is to feature biopharmaceutical aspects of a series of the most common prescription analgesics opioids.

Original languageEnglish (US)
Title of host publicationContemporary Clinical Neuroscience
PublisherSpringer Nature
Pages81-107
Number of pages27
Volume17
Edition1
DOIs
StatePublished - Nov 16 2014

Publication series

NameContemporary Clinical Neuroscience
Volume17
ISSN (Print)2627-535X
ISSN (Electronic)2627-5341

Bibliographical note

Publisher Copyright:
© 2014, Springer Science+Business Media New York.

Keywords

  • Blood Brain Barrier
  • Chronic Pain
  • Conditioned Place Preference
  • Opioid Receptor
  • Poor Metabolizers

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