Biomimetic fabrication and characterization of collagen/strontium hydroxyapatite nanocomposite

Yipin Qi, Sui Mai, Zhou Ye, Conrado Aparicio

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Strontium-releasing bioactive materials have attracted considerable attention for patients with osteoporotic bone defects due to its ability to stimulate bone formation and decrease bone resorption. In the present study, type I collagen/strontium hydroxyapatite nanocomposite (cSrHA) was fabricated via a non-classical biomimetic mineralization pathway. Mineralized collagen fibrils with nanosized SrHA embedded in intrafibrillar interstices were obtained using poly(acrylic acid) as a biomimetic mineralizing director. The resultant nanocomposite was characterized by SEM, TEM, EDS, ATR-FTIR, XRD and TGA. cSrHA displayed morphologies, nanostructures and characteristics similar to those of natural hard tissue and calcium hydroxyapatite-mineralized collagen (cCaHA), indicating its potential value as a biofunctional material for bone engineering.

Original languageEnglish (US)
Article number127982
JournalMaterials Letters
StatePublished - Sep 1 2020

Bibliographical note

Funding Information:
Parts of this work were carried out in the Characterization Facility, University of Minnesota , which receives partial support from NSF through the MRSEC program. We thank the support of the National Natural Science Foundation of China (grant number 81400506 ) and Natural Science Foundation of Guangdong Province (grant number 2018B030311040 ). The authors thank David De Jong for editing the language of this paper. The authors also acknowledge Neus Bahí Vives for technical assistance with TGA. The authors declare no competing interests.

Publisher Copyright:
© 2020 Elsevier B.V.


  • Biomimetic
  • Nanocomposites
  • Nanocrystals
  • Strontium hydroxyapatite
  • Type I collagen

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