Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration. This article discusses various classes of biomaterials currently used in craniofacial reconstruction. Also reviewed are clinical applications of biomaterials as delivery agents for sustained release of stem cells, genes, and growth factors. Recent promising advancements in 3D printing and bioprinting techniques that seem to be promising for future clinical treatments for craniofacial reconstruction are covered. Relevant topics in the bone regeneration literature exemplifying the potential of biomaterials to repair bone defects are highlighted.
Bibliographical noteFunding Information:
The authors acknowledge funding from the National Institute of Dental and Craniofacial Research , National Institutes of Health ( R01DE026170 to LEB), and the Medical Research Foundation of Oregon (to LEB).
© 2017 Elsevier Inc.
Copyright 2017 Elsevier B.V., All rights reserved.
- 3D bioprinting
- Bone regeneration
- Calcium phosphate
- Gene delivery
- Growth factor delivery
- Stem cells
- Tissue engineering