Biomaterials for Craniofacial Bone Regeneration

Greeshma Thrivikraman; Avathamsa Athirasala; Chelsea Twohig; Sunil Kumar Boda; Luiz E. Bertassoni

doi:10.1016/j.cden.2017.06.003

Biomaterials for Craniofacial Bone Regeneration

Greeshma Thrivikraman, Avathamsa Athirasala, Chelsea Twohig, Sunil Kumar Boda, Luiz E. Bertassoni

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration. This article discusses various classes of biomaterials currently used in craniofacial reconstruction. Also reviewed are clinical applications of biomaterials as delivery agents for sustained release of stem cells, genes, and growth factors. Recent promising advancements in 3D printing and bioprinting techniques that seem to be promising for future clinical treatments for craniofacial reconstruction are covered. Relevant topics in the bone regeneration literature exemplifying the potential of biomaterials to repair bone defects are highlighted.

Original language	English (US)
Pages (from-to)	835-856
Number of pages	22
Journal	Dental clinics of North America
Volume	61
Issue number	4
DOIs	https://doi.org/10.1016/j.cden.2017.06.003
State	Published - Oct 2017
Externally published	Yes

Bibliographical note

Funding Information:
The authors acknowledge funding from the National Institute of Dental and Craniofacial Research , National Institutes of Health ( R01DE026170 to LEB), and the Medical Research Foundation of Oregon (to LEB).

Publisher Copyright:
© 2017 Elsevier Inc.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

3D bioprinting
Bone regeneration
Calcium phosphate
Gene delivery
Growth factor delivery
Stem cells
Tissue engineering

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title = "Biomaterials for Craniofacial Bone Regeneration",

abstract = "Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration. This article discusses various classes of biomaterials currently used in craniofacial reconstruction. Also reviewed are clinical applications of biomaterials as delivery agents for sustained release of stem cells, genes, and growth factors. Recent promising advancements in 3D printing and bioprinting techniques that seem to be promising for future clinical treatments for craniofacial reconstruction are covered. Relevant topics in the bone regeneration literature exemplifying the potential of biomaterials to repair bone defects are highlighted.",

keywords = "3D bioprinting, Bone regeneration, Calcium phosphate, Gene delivery, Growth factor delivery, Stem cells, Tissue engineering",

author = "Greeshma Thrivikraman and Avathamsa Athirasala and Chelsea Twohig and Boda, {Sunil Kumar} and Bertassoni, {Luiz E.}",

note = "Funding Information: The authors acknowledge funding from the National Institute of Dental and Craniofacial Research , National Institutes of Health ( R01DE026170 to LEB), and the Medical Research Foundation of Oregon (to LEB). Publisher Copyright: {\textcopyright} 2017 Elsevier Inc. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2017",

month = oct,

doi = "10.1016/j.cden.2017.06.003",

language = "English (US)",

volume = "61",

pages = "835--856",

journal = "Dental Clinics of North America",

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AU - Thrivikraman, Greeshma

AU - Athirasala, Avathamsa

AU - Twohig, Chelsea

AU - Boda, Sunil Kumar

AU - Bertassoni, Luiz E.

N1 - Funding Information: The authors acknowledge funding from the National Institute of Dental and Craniofacial Research , National Institutes of Health ( R01DE026170 to LEB), and the Medical Research Foundation of Oregon (to LEB). Publisher Copyright: © 2017 Elsevier Inc. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2017/10

Y1 - 2017/10

N2 - Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration. This article discusses various classes of biomaterials currently used in craniofacial reconstruction. Also reviewed are clinical applications of biomaterials as delivery agents for sustained release of stem cells, genes, and growth factors. Recent promising advancements in 3D printing and bioprinting techniques that seem to be promising for future clinical treatments for craniofacial reconstruction are covered. Relevant topics in the bone regeneration literature exemplifying the potential of biomaterials to repair bone defects are highlighted.

AB - Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration. This article discusses various classes of biomaterials currently used in craniofacial reconstruction. Also reviewed are clinical applications of biomaterials as delivery agents for sustained release of stem cells, genes, and growth factors. Recent promising advancements in 3D printing and bioprinting techniques that seem to be promising for future clinical treatments for craniofacial reconstruction are covered. Relevant topics in the bone regeneration literature exemplifying the potential of biomaterials to repair bone defects are highlighted.

KW - 3D bioprinting

KW - Bone regeneration

KW - Calcium phosphate

KW - Gene delivery

KW - Growth factor delivery

KW - Stem cells

KW - Tissue engineering

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DO - 10.1016/j.cden.2017.06.003

M3 - Review article

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JO - Dental Clinics of North America

JF - Dental Clinics of North America

SN - 0011-8532

IS - 4

ER -

Biomaterials for Craniofacial Bone Regeneration

Abstract

Bibliographical note

Keywords

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