Biomaterial scaffolds for non-invasive focal hyperthermia as a potential tool to ablate metastatic cancer cells

Francisco Pelaez, Navid Manuchehrabadi, Priyatanu Roy, Harishankar Natesan, Yiru Wang, Emilian Racila, Heather Fong, Kevin Zeng, Abby M. Silbaugh, John C. Bischof, Samira M. Azarin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Currently, there are very few therapeutic options for treatment of metastatic disease, as it often remains undetected until the burden of disease is too high. Microporous poly(ε-caprolactone) biomaterials have been shown to attract metastasizing breast cancer cells in vivo early in tumor progression. In order to enhance the therapeutic potential of these scaffolds, they were modified such that infiltrating cells could be eliminated with non-invasive focal hyperthermia. Metal disks were incorporated into poly(ε-caprolactone) scaffolds to generate heat through electromagnetic induction by an oscillating magnetic field within a radiofrequency coil. Heat generation was modulated by varying the size of the metal disk, the strength of the magnetic field (at a fixed frequency), or the type of metal. When implanted subcutaneously in mice, the modified scaffolds were biocompatible and became properly integrated with the host tissue. Optimal parameters for in vivo heating were identified through a combination of computational modeling and ex vivo characterization to both predict and verify heat transfer dynamics and cell death kinetics during inductive heating. In vivo inductive heating of implanted, tissue-laden composite scaffolds led to tissue necrosis as seen by histological analysis. The ability to thermally ablate captured cells non-invasively using biomaterial scaffolds has the potential to extend the application of focal thermal therapies to disseminated cancers.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalBiomaterials
Volume166
DOIs
StatePublished - Jun 1 2018

Fingerprint

Biocompatible Materials
Biomaterials
Scaffolds
Fever
Hot Temperature
Cells
Heating
Metals
Magnetic Fields
Neoplasms
Tissue
Electromagnetic Phenomena
Magnetic fields
Electromagnetic induction
Heat generation
Cell death
Cell Death
Necrosis
Therapeutics
Breast Neoplasms

Keywords

  • Cancer therapy
  • Composite scaffold
  • Focal hyperthermia
  • Induction heating

How much support was provided by MRSEC?

  • Shared

Reporting period for MRSEC

  • Period 5

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

Cite this

Biomaterial scaffolds for non-invasive focal hyperthermia as a potential tool to ablate metastatic cancer cells. / Pelaez, Francisco; Manuchehrabadi, Navid; Roy, Priyatanu; Natesan, Harishankar; Wang, Yiru; Racila, Emilian; Fong, Heather; Zeng, Kevin; Silbaugh, Abby M.; Bischof, John C.; Azarin, Samira M.

In: Biomaterials, Vol. 166, 01.06.2018, p. 27-37.

Research output: Contribution to journalArticle

Pelaez, Francisco ; Manuchehrabadi, Navid ; Roy, Priyatanu ; Natesan, Harishankar ; Wang, Yiru ; Racila, Emilian ; Fong, Heather ; Zeng, Kevin ; Silbaugh, Abby M. ; Bischof, John C. ; Azarin, Samira M. / Biomaterial scaffolds for non-invasive focal hyperthermia as a potential tool to ablate metastatic cancer cells. In: Biomaterials. 2018 ; Vol. 166. pp. 27-37.
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