TY - JOUR
T1 - Biomarkers of inflammation and oxidative stress among adult former smoker, current e-cigarette users—results from wave 1 PATH study
AU - Christensen, Carol H.
AU - Chang, Joanne T.
AU - Rostron, Brian L.
AU - Hammad, Hoda T.
AU - van Bemmel, Dana M.
AU - Del Valle-Pinero, Arseima Y.
AU - Wang, Baoguang
AU - Mishina, Elena V.
AU - Faulcon, Lisa M.
AU - DePina, Ana
AU - Brown-Baker, La Nissa
AU - Kimmel, Heather L.
AU - Lambert, Elizabeth
AU - Blount, Benjamin C.
AU - Vesper, Huber W.
AU - Wang, Lanqing
AU - Goniewicz, Maciej L.
AU - Hyland, Andrew
AU - Travers, Mark J.
AU - Hatsukami, Dorothy K.
AU - Niaura, Raymond
AU - Cummings, K. Michael
AU - Taylor, Kristie A.
AU - Edwards, Kathryn C.
AU - Borek, Nicolette
AU - Ambrose, Bridget K.
AU - Chang, Cindy M.
N1 - Publisher Copyright:
© 2021 American Association for Cancer Research
PY - 2021/10
Y1 - 2021/10
N2 - Background: Former smokers who currently use e-cigarettes have lower concentrations of biomarkers of tobacco toxicant exposure than current smokers. It is unclear whether tobacco toxicant exposure reductions may lead to health risk reductions. Methods: We compared inflammatory biomarkers (high-sensitivity C-reactive protein, IL6, fibrinogen, soluble intercellular adhesion molecule-1) and an oxidative stress marker (F2-isoprostane) among 3,712 adult participants in Wave 1 (2013–2014) of the Population Assessment of Tobacco and Health Study by tobacco user groups: dual users of cigarettes and e-cigarettes; former smokers who currently use e-cigarettes-only; current cigarette-only smokers; former smokers who do not currently use any tobacco; and never tobacco users. We calculated geometric means (GM) and estimated adjusted GM ratios (GMR). Results: Dual users experienced greater concentration of F2-isoprostane than current cigarette-only smokers [GMR 1.09 (95% confidence interval, CI, 1.03–1.15)]. Biomarkers were similar between former smokers who currently use e-cigarettes and both former smokers who do not use any tobacco and never tobacco users, but among these groups most biomarkers were lower than those of current cigarette-only smokers. The concentration of F2-isoprostane decreased by time since smoking cessation among both exclusive e-cigarette users (Ptrend ¼ 0.03) and former smokers who do not currently use any tobacco (Ptrend ¼ 0.0001). Conclusions: Dual users have greater concentration of F2-isoprostane than smokers. Exclusive e-cigarette users have biomarker concentrations that are similar to those of former smokers who do not currently use tobacco, and lower than those of exclusive cigarette smokers. Impact: This study contributes to an understanding of the health effects of e-cigarettes.
AB - Background: Former smokers who currently use e-cigarettes have lower concentrations of biomarkers of tobacco toxicant exposure than current smokers. It is unclear whether tobacco toxicant exposure reductions may lead to health risk reductions. Methods: We compared inflammatory biomarkers (high-sensitivity C-reactive protein, IL6, fibrinogen, soluble intercellular adhesion molecule-1) and an oxidative stress marker (F2-isoprostane) among 3,712 adult participants in Wave 1 (2013–2014) of the Population Assessment of Tobacco and Health Study by tobacco user groups: dual users of cigarettes and e-cigarettes; former smokers who currently use e-cigarettes-only; current cigarette-only smokers; former smokers who do not currently use any tobacco; and never tobacco users. We calculated geometric means (GM) and estimated adjusted GM ratios (GMR). Results: Dual users experienced greater concentration of F2-isoprostane than current cigarette-only smokers [GMR 1.09 (95% confidence interval, CI, 1.03–1.15)]. Biomarkers were similar between former smokers who currently use e-cigarettes and both former smokers who do not use any tobacco and never tobacco users, but among these groups most biomarkers were lower than those of current cigarette-only smokers. The concentration of F2-isoprostane decreased by time since smoking cessation among both exclusive e-cigarette users (Ptrend ¼ 0.03) and former smokers who do not currently use any tobacco (Ptrend ¼ 0.0001). Conclusions: Dual users have greater concentration of F2-isoprostane than smokers. Exclusive e-cigarette users have biomarker concentrations that are similar to those of former smokers who do not currently use tobacco, and lower than those of exclusive cigarette smokers. Impact: This study contributes to an understanding of the health effects of e-cigarettes.
UR - https://www.scopus.com/pages/publications/85116980817
UR - https://www.scopus.com/pages/publications/85116980817#tab=citedBy
U2 - 10.1158/1055-9965.EPI-21-0140
DO - 10.1158/1055-9965.EPI-21-0140
M3 - Article
C2 - 34289969
AN - SCOPUS:85116980817
SN - 1055-9965
VL - 30
SP - 1947
EP - 1955
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 10
ER -