Biomarkers of bone remodeling in children with mucopolysaccharidosis types I, II, and VI

David A. Stevenson, Kyle Rudser, Alicia Kunin-Batson, Ellen B. Fung, David Viskochil, Elsa Shapiro, Paul J. Orchard, Chester B. Whitley, Lynda E. Polgreen

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

PURPOSE: Skeletal disease causes significant morbidity in mucopolysaccharidoses (MPS), and bone remodeling processes in MPS have not been well characterized. The objective of this study was to determine if biomarkers of bone turnover are abnormal in children with specific MPS disorders (i.e. MSP-I, MPS-II, and MPS-VI) compared to healthy children. METHODS: A cross-sectional study was performed of serum biomarkers of bone formation (bone-specific alkaline phosphatase [BSAP], osteocalcin) and urine biomarkers of bone resorption (pyridinoline, deoxypyridinoline) in MPS and healthy controls. Measures of physical function and pain were obtained using the Children's Health Questionnaire (CHQ). RESULTS: The cohort consisted of 39 children with MPS (MPS-I=26; MPS-II=11; MPS-VI=4) and 51 healthy children. Adjusting for sex and Tanner stage group, MPS individuals had statistically significant increases for osteocalcin (p< 0.001), with trends toward higher BSAP (p=0.054) and urinary pyridinoline (p=0.084). These biomarkers were not significantly associated with CHQ bodily pain and physical-function scores. CONCLUSION: Osteocalcin was increased in children with MPS disorders, with trends for increases in BSAP and urinary pyridinoline, suggesting that bone remodeling is altered in children with MPS. Future studies to assess the ability of these biomarkers to quantify and monitor MPS skeletal disease in response to therapy are needed.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalJournal of Pediatric Rehabilitation Medicine
Volume7
Issue number2
DOIs
StatePublished - 2014

Keywords

  • Bone
  • dysostosis multiplex
  • lysosomal storage diseases
  • mucopolysaccharidosis

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