TY - JOUR
T1 - Biomarkers in temporomandibular disorder and trigeminal neuralgia
T2 - A conceptual framework for understanding chronic pain
AU - Doshi, Tina L.
AU - Nixdorf, Donald R.
AU - Campbell, Claudia M.
AU - Raja, Srinivasa N.
N1 - Publisher Copyright:
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2020
Y1 - 2020
N2 - In this review, we will explore the use of biomarkers in chronic pain, using the examples of two prototypical facial pain conditions: trigeminal neuralgia and temporomandibular disorder. We will discuss the main categories of biomarkers and identify various genetic/genomic, molecular, neuroradiological, and psychophysical biomarkers in both facial pain conditions, using them to compare and contrast features of neuropathic, nonneuropathic, and mixed pain. By using two distinct model facial pain conditions to explore pain biomarkers, we aim to familiarize readers with different types of biomarkers currently being studied in chronic pain and explore how these biomarkers may be used to develop new precision medicine approaches to pain diagnosis, prognosis, and management.
AB - In this review, we will explore the use of biomarkers in chronic pain, using the examples of two prototypical facial pain conditions: trigeminal neuralgia and temporomandibular disorder. We will discuss the main categories of biomarkers and identify various genetic/genomic, molecular, neuroradiological, and psychophysical biomarkers in both facial pain conditions, using them to compare and contrast features of neuropathic, nonneuropathic, and mixed pain. By using two distinct model facial pain conditions to explore pain biomarkers, we aim to familiarize readers with different types of biomarkers currently being studied in chronic pain and explore how these biomarkers may be used to develop new precision medicine approaches to pain diagnosis, prognosis, and management.
KW - biomarkers
KW - chronic pain
KW - facial pain
KW - precision medicine
KW - temporomandibular disorder
KW - trigeminal neuralgia
UR - http://www.scopus.com/inward/record.url?scp=85084833310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85084833310&partnerID=8YFLogxK
U2 - 10.1080/24740527.2019.1709163
DO - 10.1080/24740527.2019.1709163
M3 - Review article
C2 - 32923920
AN - SCOPUS:85084833310
SN - 2474-0527
VL - 4
SP - 1
EP - 18
JO - Canadian Journal of Pain
JF - Canadian Journal of Pain
IS - 1
ER -