The rates of melanoma and non-melanoma skin cancer (NMSC) have been increasing over the last twenty years in the United States, and this has been attributed to increased ultraviolet radiation exposure (UVR). Given these rising rates, preventative measures have become increasingly important to reduce the incidence and promote early detection of these cancers. Skin cancer prevention remains a challenging task to accomplish mainly due to the lack of reliable and sensitive methods to provide objective risk information that can educate and motivate individuals to avoid sunburn. Currently, minimal erythema dose (MED) is used as a marker of UVR. However, it is not an ideal marker because significant cancer-related molecular damage can occur after UVR exposure that cannot be detected by MED. Thus, over the recent years there has been significant interest in development of biomarkers indicative of exposure to UVR to improve early detection of cutaneous malignancies. Here, we will discuss emerging biomarkers for melanoma and NMSC that can help with risk stratification and targeted prevention and treatment.
Bibliographical noteFunding Information:
Funding support from the NIH/NIAMS grant K01AR064315; the Prevent Cancer Foundation research award; the Columbia University Herbert Irving Comprehensive Cancer Center (P30 CA013696); the Columbia University Skin Disease Research Center (P30 AR44535).
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
- non-melanoma skin cancer
- ultraviolet radiation
PubMed: MeSH publication types
- Journal Article