Biomarkers in Graft-Versus-Host Disease

from Prediction and Diagnosis to Insights into Complex Graft/Host Interactions

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Purpose of Review: Acute graft versus host disease (aGVHD) is a frequent cause of treatment-related mortality after allogeneic hematopoietic stem cell transplantation (alloHCT), with few effective treatment options beyond systemic steroids. Discovery of biomarkers for aGVHD may provide insight into the pathophysiology of aGVHD and suggest novel mechanisms for treatment. Recent Findings: We highlight biomarkers within innate immune activation, T-cell-mediated tissue damage, endothelial damage, dysbiosis, and poor wound healing that can be obtained prior to transplant, in the early transplant period, or at the onset of aGVHD. Summary: aGVHD biomarkers have predictive and prognostic utility but also suggest novel mechanisms of recipient tissue damage and impaired regenerative capacity. These mechanisms should be further studied and tested in therapeutic clinical trials to improve outcomes post-alloHCT.

Original languageEnglish (US)
Pages (from-to)44-52
Number of pages9
JournalCurrent Hematologic Malignancy Reports
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Graft vs Host Disease
Biomarkers
Transplants
Hematopoietic Stem Cell Transplantation
Dysbiosis
Therapeutics
Wound Healing
Steroids
Clinical Trials
T-Lymphocytes
Mortality

Keywords

  • Acute graft versus host disease
  • Biomarkers
  • Pathophysiology
  • Predictive
  • Prognostic

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Cite this

@article{664288a1e8664a11af0343688847c2cb,
title = "Biomarkers in Graft-Versus-Host Disease: from Prediction and Diagnosis to Insights into Complex Graft/Host Interactions",
abstract = "Purpose of Review: Acute graft versus host disease (aGVHD) is a frequent cause of treatment-related mortality after allogeneic hematopoietic stem cell transplantation (alloHCT), with few effective treatment options beyond systemic steroids. Discovery of biomarkers for aGVHD may provide insight into the pathophysiology of aGVHD and suggest novel mechanisms for treatment. Recent Findings: We highlight biomarkers within innate immune activation, T-cell-mediated tissue damage, endothelial damage, dysbiosis, and poor wound healing that can be obtained prior to transplant, in the early transplant period, or at the onset of aGVHD. Summary: aGVHD biomarkers have predictive and prognostic utility but also suggest novel mechanisms of recipient tissue damage and impaired regenerative capacity. These mechanisms should be further studied and tested in therapeutic clinical trials to improve outcomes post-alloHCT.",
keywords = "Acute graft versus host disease, Biomarkers, Pathophysiology, Predictive, Prognostic",
author = "He, {Fiona C} and Holtan, {Shernan G}",
year = "2018",
month = "2",
day = "1",
doi = "10.1007/s11899-018-0433-2",
language = "English (US)",
volume = "13",
pages = "44--52",
journal = "Current Hematologic Malignancy Reports",
issn = "1558-8211",
publisher = "Springer Science + Business Media",
number = "1",

}

TY - JOUR

T1 - Biomarkers in Graft-Versus-Host Disease

T2 - from Prediction and Diagnosis to Insights into Complex Graft/Host Interactions

AU - He, Fiona C

AU - Holtan, Shernan G

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Purpose of Review: Acute graft versus host disease (aGVHD) is a frequent cause of treatment-related mortality after allogeneic hematopoietic stem cell transplantation (alloHCT), with few effective treatment options beyond systemic steroids. Discovery of biomarkers for aGVHD may provide insight into the pathophysiology of aGVHD and suggest novel mechanisms for treatment. Recent Findings: We highlight biomarkers within innate immune activation, T-cell-mediated tissue damage, endothelial damage, dysbiosis, and poor wound healing that can be obtained prior to transplant, in the early transplant period, or at the onset of aGVHD. Summary: aGVHD biomarkers have predictive and prognostic utility but also suggest novel mechanisms of recipient tissue damage and impaired regenerative capacity. These mechanisms should be further studied and tested in therapeutic clinical trials to improve outcomes post-alloHCT.

AB - Purpose of Review: Acute graft versus host disease (aGVHD) is a frequent cause of treatment-related mortality after allogeneic hematopoietic stem cell transplantation (alloHCT), with few effective treatment options beyond systemic steroids. Discovery of biomarkers for aGVHD may provide insight into the pathophysiology of aGVHD and suggest novel mechanisms for treatment. Recent Findings: We highlight biomarkers within innate immune activation, T-cell-mediated tissue damage, endothelial damage, dysbiosis, and poor wound healing that can be obtained prior to transplant, in the early transplant period, or at the onset of aGVHD. Summary: aGVHD biomarkers have predictive and prognostic utility but also suggest novel mechanisms of recipient tissue damage and impaired regenerative capacity. These mechanisms should be further studied and tested in therapeutic clinical trials to improve outcomes post-alloHCT.

KW - Acute graft versus host disease

KW - Biomarkers

KW - Pathophysiology

KW - Predictive

KW - Prognostic

UR - http://www.scopus.com/inward/record.url?scp=85043250945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043250945&partnerID=8YFLogxK

U2 - 10.1007/s11899-018-0433-2

DO - 10.1007/s11899-018-0433-2

M3 - Review article

VL - 13

SP - 44

EP - 52

JO - Current Hematologic Malignancy Reports

JF - Current Hematologic Malignancy Reports

SN - 1558-8211

IS - 1

ER -