Biomarkers identification and detection based on GMR sensor and sub 13 nm magnetic nanoparticles

Yuanpeng Li, Ying Jing, Xiaofeng Yao, Balasubramanian Srinivasan, Yunhao Xu, Chengguo Xing, Jian Ping Wang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this paper, we present a ultra high sensitive (Zeptomole, 10 -21) technique to enable the detection of any potential low abundance biomarkers. We demonstrated for the first time the detection of sub 13nm high-moment magnetic nanoparticle and the implementation of a novel magnetoresistive (GMR) biosensor concept with higher sensitivity and 10 times lower external field in real biomarker sensing schemes. A potential lung cancer biomarker, interleukin-6 (IL-6), was successfully detected with extremely low concentration (as few as only 200 pieces of IL-6). Together with other features of GMR sensor systems like low-cost, portability, easy-to-use, our demonstrated device may lead to future family-based personalized medicine for cancer prevention.

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

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