Biomarkers for Assessment of Chemical Exposures From e-Cigarette Emissions

Research output: Chapter in Book/Report/Conference proceedingChapter


Biomarkers of exposure, which are usually metabolites of specific carcinogens or toxicants, can provide an objective assessment of exposure to these compounds in cigarette smokers or e-Cigarette users. This chapter reviews biomarkers of exposure commonly used in studies of cigarette smoking including exhaled carbon monoxide, nicotine and its metabolites, tobacco-specific nitrosamine metabolites, metals, and metabolites or protein addition products of polycyclic aromatic hydrocarbons, volatiles, and aromatic amines. Levels of most of these substances are generally lower in the urine of e-Cigarette users than in cigarette smokers, while levels of nicotine and its major metabolite cotinine are frequently comparable in the plasma, urine, and saliva of e-Cigarette users and cigarette smokers.

Original languageEnglish (US)
Title of host publicationAnalytical Assessment of e-Cigarettes
Subtitle of host publicationFrom Contents to Chemical and Particle Exposure Profiles
PublisherElsevier Inc.
Number of pages15
ISBN (Electronic)9780128112427
ISBN (Print)9780128112410
StatePublished - Jan 1 2017


  • Biomarker
  • Cigarette smokers
  • Cotinine
  • E-Cigarette
  • Nicotine
  • Polycyclic aromatic hydrocarbons
  • Tobacco-specific nitrosamines
  • Volatile toxicants and carcinogens


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