Abstract
Due to the high resistance (35%) to the current treatment methods in adolescent Major Depressive Disorder (MDD) and its tragic outcomes, the discovery of treatmentrelated responders is critical to developing effective treatments. In this paper, the permutation test is performed to identify statistically significant changes in anatomical characteristics during pairwise comparisons among the control group (n=27), treated MDD group (n=37), and untreated MDD group (n=15). The anatomical characteristics include: 1) anatomical connectivity defined using DTI metrics between a pair of brain regions, and 2) topological measurements of anatomical networks. With the Bonferroni correction for multiple-comparison, significant alterations in community structure and local topology were identified as the p-value < 5%, which include: 1) a reduced nodal centrality (degree and strength) on right hippocampus for treated compared to untreated group, 2) an elevated clustering coefficient and local efficiency on right lateral orbitofrontal cortex for untreated compared to the combination of control and treated groups, 3) an increased participation coefficient for untreated patients on left insula cortex in the meandiffusivity network compared to the combination of control and treated groups, and 4) a degraded module degree z-score on right caudate nucleus for all the patients compared to the control group. Two connections, hippocampus-insula in the right hemisphere and parahippocampal-insula in the left hemisphere, were found significantly altered in TR, AD, and FA due to MDD.
| Original language | English (US) |
|---|---|
| Title of host publication | 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 |
| Publisher | Institute of Electrical and Electronics Engineers Inc. |
| Pages | 1152-1155 |
| Number of pages | 4 |
| ISBN (Electronic) | 9781538636466 |
| DOIs | |
| State | Published - Oct 26 2018 |
| Event | 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States Duration: Jul 18 2018 → Jul 21 2018 |
Publication series
| Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
|---|---|
| Volume | 2018-July |
| ISSN (Print) | 1557-170X |
Other
| Other | 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 |
|---|---|
| Country | United States |
| City | Honolulu |
| Period | 7/18/18 → 7/21/18 |
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PubMed: MeSH publication types
- Journal Article
Cite this
Biomarkers for Adolescent MDD from Anatomical Connectivity and Network Topology Using Diffusion MRI. / Chu, Shu Hsien; Lenglet, Christophe; Schreiner, Mindy Westlund; Klimes-Dougan, Bonnie; Cullen, Kathryn R; Parhi, Keshab K.
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1152-1155 8512505 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2018-July).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Biomarkers for Adolescent MDD from Anatomical Connectivity and Network Topology Using Diffusion MRI
AU - Chu, Shu Hsien
AU - Lenglet, Christophe
AU - Schreiner, Mindy Westlund
AU - Klimes-Dougan, Bonnie
AU - Cullen, Kathryn R
AU - Parhi, Keshab K
PY - 2018/10/26
Y1 - 2018/10/26
N2 - Due to the high resistance (35%) to the current treatment methods in adolescent Major Depressive Disorder (MDD) and its tragic outcomes, the discovery of treatmentrelated responders is critical to developing effective treatments. In this paper, the permutation test is performed to identify statistically significant changes in anatomical characteristics during pairwise comparisons among the control group (n=27), treated MDD group (n=37), and untreated MDD group (n=15). The anatomical characteristics include: 1) anatomical connectivity defined using DTI metrics between a pair of brain regions, and 2) topological measurements of anatomical networks. With the Bonferroni correction for multiple-comparison, significant alterations in community structure and local topology were identified as the p-value < 5%, which include: 1) a reduced nodal centrality (degree and strength) on right hippocampus for treated compared to untreated group, 2) an elevated clustering coefficient and local efficiency on right lateral orbitofrontal cortex for untreated compared to the combination of control and treated groups, 3) an increased participation coefficient for untreated patients on left insula cortex in the meandiffusivity network compared to the combination of control and treated groups, and 4) a degraded module degree z-score on right caudate nucleus for all the patients compared to the control group. Two connections, hippocampus-insula in the right hemisphere and parahippocampal-insula in the left hemisphere, were found significantly altered in TR, AD, and FA due to MDD.
AB - Due to the high resistance (35%) to the current treatment methods in adolescent Major Depressive Disorder (MDD) and its tragic outcomes, the discovery of treatmentrelated responders is critical to developing effective treatments. In this paper, the permutation test is performed to identify statistically significant changes in anatomical characteristics during pairwise comparisons among the control group (n=27), treated MDD group (n=37), and untreated MDD group (n=15). The anatomical characteristics include: 1) anatomical connectivity defined using DTI metrics between a pair of brain regions, and 2) topological measurements of anatomical networks. With the Bonferroni correction for multiple-comparison, significant alterations in community structure and local topology were identified as the p-value < 5%, which include: 1) a reduced nodal centrality (degree and strength) on right hippocampus for treated compared to untreated group, 2) an elevated clustering coefficient and local efficiency on right lateral orbitofrontal cortex for untreated compared to the combination of control and treated groups, 3) an increased participation coefficient for untreated patients on left insula cortex in the meandiffusivity network compared to the combination of control and treated groups, and 4) a degraded module degree z-score on right caudate nucleus for all the patients compared to the control group. Two connections, hippocampus-insula in the right hemisphere and parahippocampal-insula in the left hemisphere, were found significantly altered in TR, AD, and FA due to MDD.
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UR - http://www.scopus.com/inward/citedby.url?scp=85056616607&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2018.8512505
DO - 10.1109/EMBC.2018.8512505
M3 - Conference contribution
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 1152
EP - 1155
BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PB - Institute of Electrical and Electronics Engineers Inc.
ER -