Biomarkers and degree of atherosclerosis are independently associated with incident atherosclerotic cardiovascular disease in a primary prevention cohort: The ARIC study

Anandita Agarwala, Salim Virani, David Couper, Lloyd Chambless, Eric Boerwinkle, Brad C. Astor, Ron C. Hoogeveen, Joe Coresh, A. Richey Sharrett, Aaron R. Folsom, Tom Mosley, Christie M. Ballantyne, Vijay Nambi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background and aims Biomarkers and atherosclerosis imaging have been studied individually for association with incident cardiovascular disease (CVD); however, limited data exist on whether the biomarkers are associated with events with a similar magnitude in the presence of atherosclerosis. In this study, we assessed whether the presence of atherosclerosis as measured by carotid intima media thickness (cIMT) affects the association between biomarkers known to be associated with coronary heart disease (CHD) and incident cardiovascular disease (CVD) in a primary prevention cohort. Methods 8127 participants from the ARIC study (4th visit, 1996–1998) were stratified as having minimal, mild, or substantial atherosclerosis by cIMT. Levels of C-reactive protein, lipoprotein-associated phospholipase A2, cardiac troponin T, N-terminal pro-brain natriuretic peptide, lipoprotein(a), cystatin C, and urine albumin to creatinine ratio were measured in each participant. Hazard ratios were used to determine the relationship between the biomarkers and incident CHD, stroke, and CVD in each category of atherosclerosis. Results While each of the biomarkers was significantly associated with risk of events overall, we found no significant differences noted in the strength of association of biomarkers with CHD, stroke, and CVD when analyzed by degree of atherosclerosis. Conclusions These findings suggest that the level of atherosclerosis does not significantly influence the association between biomarkers and CVD.

Original languageEnglish (US)
Pages (from-to)156-163
Number of pages8
JournalAtherosclerosis
Volume253
DOIs
StatePublished - Oct 1 2016

Bibliographical note

Funding Information:
V. Nambi, Research collaboration with GE (no financial support), Modest, Research Grant; Along with Roche and Baylor College of Medicine we have filed a provisional patent (patent #61721475) entitled ” Biomarkers to Improve Prediction of Heart Failure Risk”, Modest, Other.

Funding Information:
C. Ballantyne, Research grant from Roche to Baylor, Significant, Research Grant; Along with Roche and Baylor College of Medicine have filed a provisional patent (patent #61721475) entitled ” Biomarkers to Improve Prediction of Heart Failure Risk”, Modest, Other.

Keywords

  • Cardiovascular disease
  • Carotid intima media thickness
  • Coronary heart disease
  • High sensitivity C- reactive protein
  • High sensitivity troponin T
  • Lipoprotein associated phospholipase A2
  • NT-pro B-type natriuretic peptide
  • Stroke
  • lipoprotein(a)

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