Biomarkers and Cognitive Function in Children and Adolescents During Maintenance Therapy for Leukemia

Mary C. Hooke, Michelle A. Mathiason, Alicia S. Kunin-Batson, Audrey Blommer, Jessica Hutter, Pauline A. Mitby, Ida M. Moore, Susan Whitman, Olga Taylor, Michael E. Scheurer, Marilyn J. Hockenberry

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


OBJECTIVES: To explore the relationship between biomarkers of oxidative stress and inflmmation in cerebrospinal fluid (CSF) and cognitive function in children receiving maintenance therapy for acute lymphocytic leukemia (ALL). SAMPLE & SETTING: 30 participants aged 4-17 years receiving ALL maintenance therapy at two pediatric cancer centers in the United States. METHODS & VARIABLES: F2-isoprostane (F2-ISoP) and interleukin-8 (IL-8) were evaluated in CSF samples, and cognitive function measures were completed during the first and last cycles of ALL maintenance. The Flanker Inhibitory Control and Attention Test (Flanker) and Dimensional Change Card Sort were completed during the last cycle. RESULTS: During maintenance therapy, IL-8 decreased, and parent reports of children's cognitive function improved. Higher IL-8 was associated with better parent reports of children's cognitive function at each timepoint. Higher F2-ISoP levels were associated with lower Flanker scores. IMPLICATIONS FOR NURSING: F2-ISoP may be a useful biomarker in evaluating cognitive dysfunction in children with ALL and merits further investigation.

Original languageEnglish (US)
Pages (from-to)623-633
Number of pages11
JournalOncology nursing forum
Issue number6
StatePublished - Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 Oncology Nursing Society. All rights reserved.


  • acute lymphoblastic leukemia
  • biomarkers
  • childhood cancer
  • cognitive function
  • Oxidative Stress
  • Humans
  • Adolescent
  • Biomarkers
  • F2-Isoprostanes
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy
  • Cognition
  • Child

PubMed: MeSH publication types

  • Research Support, Non-U.S. Gov't
  • Journal Article
  • Research Support, N.I.H., Extramural


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