TY - JOUR
T1 - Biomarkers
AU - Florea, Viorel
AU - Anand, Inder
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Epidemiologic, clinical, and basic research has identified several antecedent conditions that predispose individuals to heart failure and its predecessor, asymptomatic left ventricular remodeling and dysfunction (stage B heart failure). Many biochemical markers have been described that characterize the remodeling process and the development of cardiac dysfunction. Although natriuretic peptides and cardiac troponin are currently used in the context of diagnosis, risk stratification, and management of stage C and D heart failure, many other biomarkers provide insights into the underlying pathophysiology of left ventricular dysfunction, suggesting new directions for fundamental research or the development of new therapies.
AB - Epidemiologic, clinical, and basic research has identified several antecedent conditions that predispose individuals to heart failure and its predecessor, asymptomatic left ventricular remodeling and dysfunction (stage B heart failure). Many biochemical markers have been described that characterize the remodeling process and the development of cardiac dysfunction. Although natriuretic peptides and cardiac troponin are currently used in the context of diagnosis, risk stratification, and management of stage C and D heart failure, many other biomarkers provide insights into the underlying pathophysiology of left ventricular dysfunction, suggesting new directions for fundamental research or the development of new therapies.
KW - Biomarkers
KW - Brain natriuretic peptide
KW - Heart failure
KW - Troponin
UR - http://www.scopus.com/inward/record.url?scp=84858111244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858111244&partnerID=8YFLogxK
U2 - 10.1016/j.hfc.2011.11.005
DO - 10.1016/j.hfc.2011.11.005
M3 - Review article
C2 - 22405661
AN - SCOPUS:84858111244
VL - 8
SP - 207
EP - 224
JO - Heart Failure Clinics
JF - Heart Failure Clinics
SN - 1551-7136
IS - 2
ER -