Biology of the Striated Muscle Dystrophin-Glycoprotein Complex

James M Ervasti, Kevin J. Sonnemann

Research output: Chapter in Book/Report/Conference proceedingChapter

102 Scopus citations

Abstract

Since its first description in 1990, the dystrophin-glycoprotein complex has emerged as a critical nexus for human muscular dystrophies arising from defects in a variety of distinct genes. Studies in mammals widely support a primary role for the dystrophin-glycoprotein complex in mechanical stabilization of the plasma membrane in striated muscle and provide hints for secondary functions in organizing molecules involved in cellular signaling. Studies in model organisms confirm the importance of the dystrophin-glycoprotein complex for muscle cell viability and have provided new leads toward a full understanding of its secondary roles in muscle biology.

Original languageEnglish (US)
Title of host publicationA Survey of Cell Biology
PublisherAcademic Press Inc.
Pages191-225
Number of pages35
ISBN (Print)9780123743329
DOIs
StatePublished - Jan 1 2008

Publication series

NameInternational Review of Cytology
Volume265
ISSN (Print)0074-7696

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Keywords

  • Dystrobrevin
  • Dystroglycan
  • Dystrophin
  • Sarcoglycan
  • Sarcospan
  • Syntrophin

Cite this

Ervasti, J. M., & Sonnemann, K. J. (2008). Biology of the Striated Muscle Dystrophin-Glycoprotein Complex. In A Survey of Cell Biology (pp. 191-225). (International Review of Cytology; Vol. 265). Academic Press Inc.. https://doi.org/10.1016/S0074-7696(07)65005-0