TY - JOUR
T1 - Biology of natural killer cells in cancer and infection
AU - Miller, Jeffrey S.
PY - 2002
Y1 - 2002
N2 - NK cells are the important cells of the immune system derived from stem cells in the marrow. Their physiology is tightly regulated to control proliferation, cytotoxicity and cytokine production. In cancer, NK cells may be abnormal due to the cancer itself or possibly related to its therapy. The finding of class I recognizing inhibitory receptors may play a role in stem cell transplant rejection, immune surveillance and cancer immunotherapy. NK cells should no longer be thought of as direct cytotoxic killers alone, as they clearly play a critical role in cytokine production which may be important to control cancer and infection. Understanding NK cell function and homing may lead to novel therapeutic strategies for the treatment of human disease.
AB - NK cells are the important cells of the immune system derived from stem cells in the marrow. Their physiology is tightly regulated to control proliferation, cytotoxicity and cytokine production. In cancer, NK cells may be abnormal due to the cancer itself or possibly related to its therapy. The finding of class I recognizing inhibitory receptors may play a role in stem cell transplant rejection, immune surveillance and cancer immunotherapy. NK cells should no longer be thought of as direct cytotoxic killers alone, as they clearly play a critical role in cytokine production which may be important to control cancer and infection. Understanding NK cell function and homing may lead to novel therapeutic strategies for the treatment of human disease.
UR - http://www.scopus.com/inward/record.url?scp=0036252621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036252621&partnerID=8YFLogxK
U2 - 10.1081/CNV-120001185
DO - 10.1081/CNV-120001185
M3 - Article
C2 - 12025235
AN - SCOPUS:0036252621
SN - 0735-7907
VL - 20
SP - 405
EP - 419
JO - Cancer Investigation
JF - Cancer Investigation
IS - 3
ER -