Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment

Y. Riviere, P. J. Southern, R. Ahmed, M. B.A. Oldstone

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Lymphocytic choriomeningitis virus (LCMV) Armstrong (ARM) strain-specific, H-2(d)-restricted CTL effectively lyse syngeneic targets infected by LCMV ARM, but show reduced killing of LCMV Pasteur (PAST) strain-infected H-2(d) cells. We have reassorted the two RNA segments, large (L) and small (S), of LCMV ARM and PAST to generate LCMV with genotypes of L ARM/S PAST and L PAST/S ARM. By using these reassortants and both LCMV primary CTL and CTL clones, we report that the induction, recognition, and lysis of LCMV-specific CTL depend on the S RNA segment and the genes it encodes.

Original languageEnglish (US)
Pages (from-to)304-307
Number of pages4
JournalJournal of Immunology
Volume136
Issue number1
StatePublished - 1986

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