TY - JOUR
T1 - Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment
AU - Riviere, Y.
AU - Southern, P. J.
AU - Ahmed, R.
AU - Oldstone, M. B.A.
PY - 1986
Y1 - 1986
N2 - Lymphocytic choriomeningitis virus (LCMV) Armstrong (ARM) strain-specific, H-2(d)-restricted CTL effectively lyse syngeneic targets infected by LCMV ARM, but show reduced killing of LCMV Pasteur (PAST) strain-infected H-2(d) cells. We have reassorted the two RNA segments, large (L) and small (S), of LCMV ARM and PAST to generate LCMV with genotypes of L ARM/S PAST and L PAST/S ARM. By using these reassortants and both LCMV primary CTL and CTL clones, we report that the induction, recognition, and lysis of LCMV-specific CTL depend on the S RNA segment and the genes it encodes.
AB - Lymphocytic choriomeningitis virus (LCMV) Armstrong (ARM) strain-specific, H-2(d)-restricted CTL effectively lyse syngeneic targets infected by LCMV ARM, but show reduced killing of LCMV Pasteur (PAST) strain-infected H-2(d) cells. We have reassorted the two RNA segments, large (L) and small (S), of LCMV ARM and PAST to generate LCMV with genotypes of L ARM/S PAST and L PAST/S ARM. By using these reassortants and both LCMV primary CTL and CTL clones, we report that the induction, recognition, and lysis of LCMV-specific CTL depend on the S RNA segment and the genes it encodes.
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M3 - Article
C2 - 3484391
AN - SCOPUS:0022653875
SN - 0022-1767
VL - 136
SP - 304
EP - 307
JO - Journal of Immunology
JF - Journal of Immunology
IS - 1
ER -