Biology of bone cancer pain

Patrick W. O’Donnell, Denis R. Clohisy

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Bone cancer pain is a complex process with many potential targets for therapeutic intervention. As pain is the most common presenting symptom in patients with skeletal metastases and is directly proportional to the patient’s quality of life, clinical advancements in the treatment of bone cancer pain are of the utmost importance. Research targeting pain-related cytokines, anti-osteoclastic medications, and ion channels has shown significant clinical progress in the treatment of cancer-related bone pain. With continued efforts into these and other therapeutic strategies, we hope to continue to improve the quality of life of those patients suffering with bone cancer pain.

Original languageEnglish (US)
Title of host publicationMetastatic Bone Disease
Subtitle of host publicationAn Integrated Approach to Patient Care
PublisherSpringer New York
Number of pages8
ISBN (Electronic)9781461456629
ISBN (Print)9781461456612
StatePublished - Jan 1 2015

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2016.


  • Bisphosphonates
  • Bone cancer
  • Denosumab
  • Ion channels
  • Osteoclast
  • Pain
  • Skeletal metastasis


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