Biology evolves to fight chemistry

Romas Kazlauskas

doi:10.1016/j.chembiol.2012.04.004

Biology evolves to fight chemistry

Romas Kazlauskas

Synthetic Biology and Biotechnology Division

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.

Original language	English (US)
Pages (from-to)	435-437
Number of pages	3
Journal	Chemistry and Biology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.chembiol.2012.04.004
State	Published - Apr 20 2012

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10.1016/j.chembiol.2012.04.004

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title = "Biology evolves to fight chemistry",

abstract = "A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry \& Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.",

author = "Romas Kazlauskas",

year = "2012",

month = apr,

day = "20",

doi = "10.1016/j.chembiol.2012.04.004",

language = "English (US)",

volume = "19",

pages = "435--437",

journal = "Chemistry and Biology",

issn = "1074-5521",

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number = "4",

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TY - JOUR

T1 - Biology evolves to fight chemistry

AU - Kazlauskas, Romas

PY - 2012/4/20

Y1 - 2012/4/20

N2 - A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.

AB - A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.

UR - https://www.scopus.com/pages/publications/84860204671

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U2 - 10.1016/j.chembiol.2012.04.004

DO - 10.1016/j.chembiol.2012.04.004

M3 - Short survey

C2 - 22520746

AN - SCOPUS:84860204671

SN - 1074-5521

VL - 19

SP - 435

EP - 437

JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 4

ER -

Biology evolves to fight chemistry

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