Biology and Hemodynamics of Aneurysm Rupture

Casey A. Chitwood, Elizabeth D. Shih, Omid Amili, Anthony S. Larson, Brenda M. Ogle, Patrick W. Alford, Andrew W. Grande

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Predicting rupture risk in intracranial aneurysms is among one of the most critical questions in vascular surgery. The processes that govern an aneurysm growth are multifaceted and complex, but may be summarized into three components: hemodynamics, biology, and mechanics. We review and connect the literature in the three disciplines, identifying considerable strides in recent history and current gaps in research. Taken together, the findings from each field elucidate how and why certain aneurysms rupture, whereas others remain stable. These parameters could eventually inform a translatable predictive model that optimizes risk evaluation and physician's decision-making in treatment options for aneurysms.

Original languageEnglish (US)
Pages (from-to)431-441
Number of pages11
JournalNeurosurgery clinics of North America
Issue number4
StatePublished - Oct 2022

Bibliographical note

Funding Information:
The authors have no conflicts of interest to declare.


  • Biology
  • Hemodynamics
  • Intracranial aneurysms
  • Mechanics
  • Predictive modeling
  • Rupture
  • Humans
  • Intracranial Aneurysm/surgery
  • Aneurysm, Ruptured/surgery

PubMed: MeSH publication types

  • Journal Article
  • Review


Dive into the research topics of 'Biology and Hemodynamics of Aneurysm Rupture'. Together they form a unique fingerprint.

Cite this