Biology and Hemodynamics of Aneurysm Rupture

Casey A Chitwood; Elizabeth Shih; Omid Amili; Anthony S. Larson; Brenda M. Ogle; Patrick W. Alford; Andrew W. Grande

doi:10.1016/j.nec.2022.06.002

Biology and Hemodynamics of Aneurysm Rupture

Casey A Chitwood, Elizabeth Shih, Omid Amili, Anthony S. Larson, Brenda M. Ogle, Patrick W. Alford, Andrew W. Grande

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Predicting rupture risk in intracranial aneurysms is among one of the most critical questions in vascular surgery. The processes that govern an aneurysm growth are multifaceted and complex, but may be summarized into three components: hemodynamics, biology, and mechanics. We review and connect the literature in the three disciplines, identifying considerable strides in recent history and current gaps in research. Taken together, the findings from each field elucidate how and why certain aneurysms rupture, whereas others remain stable. These parameters could eventually inform a translatable predictive model that optimizes risk evaluation and physician's decision-making in treatment options for aneurysms.

Original language	English (US)
Pages (from-to)	431-441
Number of pages	11
Journal	Neurosurgery clinics of North America
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.nec.2022.06.002
State	Published - Oct 2022

Bibliographical note

Funding Information:
The authors have no conflicts of interest to declare.

Keywords

Biology
Hemodynamics
Intracranial aneurysms
Mechanics
Predictive modeling
Rupture
Humans
Intracranial Aneurysm/surgery
Aneurysm, Ruptured/surgery

PubMed: MeSH publication types

Journal Article
Review

Publisher link

10.1016/j.nec.2022.06.002

Find It

Find It at U of M Libraries

Cite this

@article{ebc4b95d9f2a4503aa4442aacf1df692,

title = "Biology and Hemodynamics of Aneurysm Rupture",

abstract = "Predicting rupture risk in intracranial aneurysms is among one of the most critical questions in vascular surgery. The processes that govern an aneurysm growth are multifaceted and complex, but may be summarized into three components: hemodynamics, biology, and mechanics. We review and connect the literature in the three disciplines, identifying considerable strides in recent history and current gaps in research. Taken together, the findings from each field elucidate how and why certain aneurysms rupture, whereas others remain stable. These parameters could eventually inform a translatable predictive model that optimizes risk evaluation and physician's decision-making in treatment options for aneurysms.",

keywords = "Biology, Hemodynamics, Intracranial aneurysms, Mechanics, Predictive modeling, Rupture, Humans, Intracranial Aneurysm/surgery, Aneurysm, Ruptured/surgery",

author = "Chitwood, {Casey A} and Elizabeth Shih and Omid Amili and Larson, {Anthony S.} and Ogle, {Brenda M.} and Alford, {Patrick W.} and Grande, {Andrew W.}",

note = "Funding Information: The authors have no conflicts of interest to declare.",

year = "2022",

month = oct,

doi = "10.1016/j.nec.2022.06.002",

language = "English (US)",

volume = "33",

pages = "431--441",

journal = "Neurosurgery clinics of North America",

issn = "1042-3680",

publisher = "W.B. Saunders Ltd",

number = "4",

}

TY - JOUR

T1 - Biology and Hemodynamics of Aneurysm Rupture

AU - Chitwood, Casey A

AU - Shih, Elizabeth

AU - Amili, Omid

AU - Larson, Anthony S.

AU - Ogle, Brenda M.

AU - Alford, Patrick W.

AU - Grande, Andrew W.

N1 - Funding Information: The authors have no conflicts of interest to declare.

PY - 2022/10

Y1 - 2022/10

N2 - Predicting rupture risk in intracranial aneurysms is among one of the most critical questions in vascular surgery. The processes that govern an aneurysm growth are multifaceted and complex, but may be summarized into three components: hemodynamics, biology, and mechanics. We review and connect the literature in the three disciplines, identifying considerable strides in recent history and current gaps in research. Taken together, the findings from each field elucidate how and why certain aneurysms rupture, whereas others remain stable. These parameters could eventually inform a translatable predictive model that optimizes risk evaluation and physician's decision-making in treatment options for aneurysms.

AB - Predicting rupture risk in intracranial aneurysms is among one of the most critical questions in vascular surgery. The processes that govern an aneurysm growth are multifaceted and complex, but may be summarized into three components: hemodynamics, biology, and mechanics. We review and connect the literature in the three disciplines, identifying considerable strides in recent history and current gaps in research. Taken together, the findings from each field elucidate how and why certain aneurysms rupture, whereas others remain stable. These parameters could eventually inform a translatable predictive model that optimizes risk evaluation and physician's decision-making in treatment options for aneurysms.

KW - Biology

KW - Hemodynamics

KW - Intracranial aneurysms

KW - Mechanics

KW - Predictive modeling

KW - Rupture

KW - Humans

KW - Intracranial Aneurysm/surgery

KW - Aneurysm, Ruptured/surgery

UR - http://www.scopus.com/inward/record.url?scp=85137674753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85137674753&partnerID=8YFLogxK

U2 - 10.1016/j.nec.2022.06.002

DO - 10.1016/j.nec.2022.06.002

M3 - Review article

C2 - 36229130

AN - SCOPUS:85137674753

SN - 1042-3680

VL - 33

SP - 431

EP - 441

JO - Neurosurgery clinics of North America

JF - Neurosurgery clinics of North America

IS - 4

ER -

Biology and Hemodynamics of Aneurysm Rupture

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Publisher link

Find It

Other files and links

Fingerprint

Cite this