Biological rhythms, drug delivery, and chronotherapeutics

Michael H. Smolensky, Ronald A. Siegel, Erhard Haus, Ramon Hermida, Francesco Portaluppi

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations


Biological processes are highly structured in time as endogenously derived rhythms of short, intermediate, and long periods, with the circadian (24 h) time structure most studied. Staging of key physiological and biochemical circadian rhythms gives rise to 24-h patterns in the exacerbation of chronic medical conditions, including arthritis, asthma, ulcer, and hypertension, plus manifestation of acute severe morbid and mortal events, such as myocardial infarction, stroke, and sudden cardiac death. Body rhythms may also significantly affect patient response to diagnostic tests and pharmacokinetics, pharmacodynamics, and toxicities of diverse classes of medications. This chapter reviews circadian and other period biological rhythm dependencies of the pathophysiology of disease and pharmacology of medications as the basis for chronotherapeutics and development of time-modulated drug-delivery systems.

Original languageEnglish (US)
Title of host publicationFundamentals and Applications of Controlled Release Drug Delivery
PublisherSpringer US
Number of pages85
ISBN (Electronic)9781461408819
ISBN (Print)9781461408802
StatePublished - Jan 1 2012

Bibliographical note

Publisher Copyright:
© 2012, Controlled Release Society.


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