Biological implications of cell fusion

Brenda M. Ogle; Marilia Cascalho; Jeffrey L. Platt

doi:10.1038/nrm1678

Biological implications of cell fusion

Brenda M. Ogle, Marilia Cascalho, Jeffrey L. Platt

Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

275 Scopus citations

Abstract

Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins, The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.

Original language	English (US)
Pages (from-to)	567-575
Number of pages	9
Journal	Nature Reviews Molecular Cell Biology
Volume	6
Issue number	7
DOIs	https://doi.org/10.1038/nrm1678
State	Published - Jul 2005

Bibliographical note

Funding Information:
Work in the authors’ laboratory is supported by grants from the National Institutes of Health.

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10.1038/nrm1678

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title = "Biological implications of cell fusion",

abstract = "Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins, The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.",

author = "Ogle, {Brenda M.} and Marilia Cascalho and Platt, {Jeffrey L.}",

note = "Funding Information: Work in the authors{\textquoteright} laboratory is supported by grants from the National Institutes of Health.",

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AU - Cascalho, Marilia

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N2 - Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins, The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.

AB - Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins, The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.

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Biological implications of cell fusion

Abstract

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