Biological implications of cell fusion

Brenda M. Ogle, Marilia Cascalho, Jeffrey L. Platt

Research output: Contribution to journalReview articlepeer-review

221 Scopus citations


Until recently, cells were thought to be integral and discrete components of tissues, and their state was determined by cell differentiation. However, under some conditions, stem cells or their progeny can fuse with cells of other types, mixing cytoplasmic and even genetic material of different (heterotypic) origins, The fusion of heterotypic cells could be of central importance for development, repair of tissues and the pathogenesis of disease.

Original languageEnglish (US)
Pages (from-to)567-575
Number of pages9
JournalNature Reviews Molecular Cell Biology
Issue number7
StatePublished - Jul 2005

Bibliographical note

Funding Information:
Work in the authors’ laboratory is supported by grants from the National Institutes of Health.


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