TY - JOUR
T1 - Biological evaluation of novel 6-Arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
AU - Galarce, Gloria D.
AU - Foncea, Rocío E.
AU - Edwards, Ana M.
AU - Pessoa-Mahana, Hernán
AU - Pessoa-Mahana, Carlos D.
AU - Ebensperger, Roberto A.
PY - 2008
Y1 - 2008
N2 - This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-α) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-α secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo[1,2-c]quinazoline, coded as G1, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo[1,2-c]quinazoline derivatives may have a potential as anti-inflammatory agents.
AB - This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-α) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-α secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo[1,2-c]quinazoline, coded as G1, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo[1,2-c]quinazoline derivatives may have a potential as anti-inflammatory agents.
KW - Anti-inflammatory agents
KW - Benzimidazoquinazoline derivatives
KW - TNF-α inhibitors
UR - http://www.scopus.com/inward/record.url?scp=51449107911&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51449107911&partnerID=8YFLogxK
U2 - 10.4067/S0716-97602008000100006
DO - 10.4067/S0716-97602008000100006
M3 - Article
C2 - 18769762
AN - SCOPUS:51449107911
SN - 0716-9760
VL - 41
SP - 43
EP - 50
JO - Biological Research
JF - Biological Research
IS - 1
ER -
