Biological effects of boron-absorbed C6 glioma cells irradiated by UHZr reactor neutron source

Xinbiao Jiang, Ying Zhao, Ruifeng Cao, Yan Xiao, Wei Chen, Jing Tu, Xiang Zhang

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1 Scopus citations

Abstract

A neutron source of UHZr reactor for C6 glioma cells irradiation is designed by MCNP/4B code. Methods for cell culture, incubation, L-BPA administration, boron concentration measurement and the irradiation experiment are described. Radiobiological effects of C6 glioma cells in vitro, which are induced by BNCT, and the relations between the biological effect and the irradiation dose are studied. The results demonstrate that the cytocidal effect of the BNCT method is much more remarkable than that of gamma radiotherapy at the same absorbed dose.

Original languageEnglish (US)
Pages (from-to)458-462
Number of pages5
JournalHe Jishu/Nuclear Techniques
Volume28
Issue number6
StatePublished - Jun 2005

Keywords

  • Biological effect
  • Boron neutron capture therapy (BNCT)
  • C6 glioma cell
  • Uranium hydrogen zirconium reactor

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