Biological aging - Criteria for modeling and a new mechanistic model

Scott D. Pletcher, Claudia Neuhauser

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

To stimulate interaction and collaboration across scientific fields, we introduce a minimum set of biological criteria that theoretical models of aging should satisfy. We review results of several recent experiments that examined changes in age-specific mortality rates caused by genetic and environmental manipulation. The empirical data from these experiments is then used to test mathematical models of aging from several different disciplines, including molecular biology, reliability theory, physics, and evolutionary biology/population genetics. We find that none of the current models are consistent with all of the published experimental findings. To provide an example of how our criteria might be applied in practice, we develop a new conceptual model of aging that is consistent with our observations.

Original languageEnglish (US)
Pages (from-to)525-546
Number of pages22
JournalInternational Journal of Modern Physics C
Volume11
Issue number3
DOIs
StatePublished - May 2000

Keywords

  • Age-Specific Mortality
  • Evolution
  • Mutation Accumulation
  • Penna Model
  • Redundancy Models

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